Market Cap 6.66B
Revenue (ttm) 46.02M
Net Income (ttm) -130.15M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE 42.77
Profit Margin -282.81%
Debt to Equity Ratio 0.00
Volume 645,700
Avg Vol 790,934
Day's Range N/A - N/A
Shares Out 64.31M
Stochastic %K 35%
Beta 1.89
Analysts Strong Sell
Price Target $116.31

Company Profile

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is al...

Industry: Biotechnology
Sector: Healthcare
Phone: 510 474 0170
Address:
7707 Gateway Boulevard, Suite 140, Newark, United States
Quantumup
Quantumup May. 11 at 1:44 PM
BMO Capital reiterated $PTGX Outperform; $112, and said: Main Character Energy—Momentum Increases Upside Potential for PTGX. $JNJ $TAK ABBV BMY ALMS ABVX BMO Capital added—Commercial launches and anticipated approvals could enable accelerated clinical diversification and growth for Protagonist. As of March 31, 2026, the company held cash and cash equivalents of $620M, with an anticipated runway through ~2028. Following the recent Icotyde approval (here) and launch, we could see potential additional indication approvals for the product into the decade, and a nearer-term rusfertide approval later this year (Aug. 2026 PDUFA). We continue to like collaboration revenue opportunities supportive of clinical development/diversification and look for clinical derisking of earlier-stage assets for growth beyond Icotyde/rusfertide.
0 · Reply
EmergingMarketDebt
EmergingMarketDebt May. 10 at 5:52 PM
$PTGX Biotechnology company focused on gastrointestinal and specialty-treatment development
0 · Reply
DonCorleone77
DonCorleone77 May. 10 at 3:29 PM
$PTGX Protagonist Therapeutics price target raised to $130 from $125 at Citi Citi raised the firm's price target on Protagonist Therapeutics to $130 from $125 and keeps a Buy rating on the shares. The firm updated the company's model post the Q1 report. It views Protagonist's quarter as "transformative" with the Icotyde approval.
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Merlintrader
Merlintrader May. 9 at 4:27 PM
$UNCY Three 2026 FDA Decisions Testing Whether New Drugs Can Beat Imperfect Standards: Unicycive, Protagonist and Savara. $PTGX $SVRA) https://www.merlintrader.com/three-2026-fda-decisions/
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History101
History101 May. 5 at 10:48 PM
$PTGX was just introduced to this stock by an excellent CNBC Fast Money segment featuring the CEO. Plan to buy tomorrow. GLTALs!!
0 · Reply
History101
History101 May. 5 at 10:26 PM
$PTGX 3,352 watching 5/5/2026
0 · Reply
biotechdeeppro
biotechdeeppro Apr. 25 at 6:25 PM
$ALMS $100 is a far reach. $40-50 is most likely. hard to see anyone want to buy out it until new data comes out in the fall earliest. Approval may be 1 year away. JNJ's drug $PTGX is already on the market and has the first move advantage. Takeda's drug is more convenient as QD vs. ALMS's BID. $ALMS might have to prove the drug can significant revenue, or obtain good data in other indications, comparing to JNJ's and Takeda's, before any big pharma will buy it out. before that, $30 is the ceiling.
0 · Reply
Quantumup
Quantumup Apr. 22 at 8:47 PM
Morgan Stanley⬆️(a/o 4/19) $ABVX and said: Abivax (ABVX, OW, $110 to $170 Base Case Range, Current Price ~$120), Approaching Ph3 Maintenance Data in UC: $JNJ - $PTGX TEVA ROIV - RHHBY SYRE ABBV TAK PFE BMY LLY Here's what else Morgan Stanley had to say: https://x.com/Quantumup1/status/2047053518503092554?s=20
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IN0V8
IN0V8 Apr. 15 at 4:27 PM
$PTGX Buy Truist Securities raises PT to $121 from $110
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Quantumup
Quantumup Apr. 15 at 12:33 PM
H.C. Wainwright reiterated $ALMS Buy; $25 after H.C. Wainwright's 4th Annual Inflammatory Skin Disease Virtual Conference. $JNJ - $PTGX ORKA TAK BMY ABBV NVS LLY H.C. Wainwright said in its note: Per our Inflammatory Skin Disease Conference yesterday, our most important takeaways from the fireside chat with Alumis management were as follows: (1) envu may be the strongest oral TYK2, given the baseline characteristics and comparability between envu trials, (2) response may still deepen beyond Week 24, (3) twice-daily (BID) dosing is expected to be a temporary launch format (with QD on the way), and (4) differentiators from competition could be itch relief, quality of life, and prescribing simplicity (with simplicity strategy yet to be unveiled). We reiterate our Buy rating and 12-month price target of $25.
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Latest News on PTGX
Protagonist Therapeutics Reports Granting of Inducement Awards

Apr 16, 2026, 4:05 PM EDT - 26 days ago

Protagonist Therapeutics Reports Granting of Inducement Awards


Protagonist price target raised to $110 from $107 at Leerink

2026-03-19T15:41:14.000Z - 7 weeks ago

Protagonist price target raised to $110 from $107 at Leerink


Protagonist Therapeutics Transcript: FDA announcement

Mar 18, 2026, 8:30 AM EDT - 7 weeks ago

Protagonist Therapeutics Transcript: FDA announcement


RTW Investments' Rod Wong: Expect more deals in biotech space

Oct 10, 2025, 1:21 PM EDT - 7 months ago

RTW Investments' Rod Wong: Expect more deals in biotech space

JNJ XBI


Johnson & Johnson in Talks to Buy Protagonist Therapeutics

Oct 10, 2025, 11:13 AM EDT - 7 months ago

Johnson & Johnson in Talks to Buy Protagonist Therapeutics

JNJ


Protagonist Therapeutics Transcript: Status Update

Jun 30, 2025, 4:30 PM EDT - 11 months ago

Protagonist Therapeutics Transcript: Status Update


Protagonist Therapeutics Transcript: Status Update

Jun 2, 2025, 8:00 AM EDT - 1 year ago

Protagonist Therapeutics Transcript: Status Update


Protagonist Therapeutics Reports Granting of Inducement Award

Apr 16, 2025, 4:05 PM EDT - 1 year ago

Protagonist Therapeutics Reports Granting of Inducement Award


Overlooked Stock: PTGX

Mar 10, 2025, 4:57 PM EDT - 1 year ago

Overlooked Stock: PTGX


Protagonist Therapeutics Transcript: Investor Update

Mar 3, 2025, 8:30 AM EST - 1 year ago

Protagonist Therapeutics Transcript: Investor Update


Protagonist Therapeutics Transcript: Study Update

Feb 6, 2025, 10:30 AM EST - 1 year ago

Protagonist Therapeutics Transcript: Study Update


Protagonist Therapeutics Transcript: Status Update

Nov 21, 2024, 4:30 PM EST - 1 year ago

Protagonist Therapeutics Transcript: Status Update


Protagonist Therapeutics Transcript: Collaboration

Jan 31, 2024, 4:30 PM EST - 2 years ago

Protagonist Therapeutics Transcript: Collaboration


Quantumup
Quantumup May. 11 at 1:44 PM
BMO Capital reiterated $PTGX Outperform; $112, and said: Main Character Energy—Momentum Increases Upside Potential for PTGX. $JNJ $TAK ABBV BMY ALMS ABVX BMO Capital added—Commercial launches and anticipated approvals could enable accelerated clinical diversification and growth for Protagonist. As of March 31, 2026, the company held cash and cash equivalents of $620M, with an anticipated runway through ~2028. Following the recent Icotyde approval (here) and launch, we could see potential additional indication approvals for the product into the decade, and a nearer-term rusfertide approval later this year (Aug. 2026 PDUFA). We continue to like collaboration revenue opportunities supportive of clinical development/diversification and look for clinical derisking of earlier-stage assets for growth beyond Icotyde/rusfertide.
0 · Reply
EmergingMarketDebt
EmergingMarketDebt May. 10 at 5:52 PM
$PTGX Biotechnology company focused on gastrointestinal and specialty-treatment development
0 · Reply
DonCorleone77
DonCorleone77 May. 10 at 3:29 PM
$PTGX Protagonist Therapeutics price target raised to $130 from $125 at Citi Citi raised the firm's price target on Protagonist Therapeutics to $130 from $125 and keeps a Buy rating on the shares. The firm updated the company's model post the Q1 report. It views Protagonist's quarter as "transformative" with the Icotyde approval.
0 · Reply
Merlintrader
Merlintrader May. 9 at 4:27 PM
$UNCY Three 2026 FDA Decisions Testing Whether New Drugs Can Beat Imperfect Standards: Unicycive, Protagonist and Savara. $PTGX $SVRA) https://www.merlintrader.com/three-2026-fda-decisions/
0 · Reply
History101
History101 May. 5 at 10:48 PM
$PTGX was just introduced to this stock by an excellent CNBC Fast Money segment featuring the CEO. Plan to buy tomorrow. GLTALs!!
0 · Reply
History101
History101 May. 5 at 10:26 PM
$PTGX 3,352 watching 5/5/2026
0 · Reply
biotechdeeppro
biotechdeeppro Apr. 25 at 6:25 PM
$ALMS $100 is a far reach. $40-50 is most likely. hard to see anyone want to buy out it until new data comes out in the fall earliest. Approval may be 1 year away. JNJ's drug $PTGX is already on the market and has the first move advantage. Takeda's drug is more convenient as QD vs. ALMS's BID. $ALMS might have to prove the drug can significant revenue, or obtain good data in other indications, comparing to JNJ's and Takeda's, before any big pharma will buy it out. before that, $30 is the ceiling.
0 · Reply
Quantumup
Quantumup Apr. 22 at 8:47 PM
Morgan Stanley⬆️(a/o 4/19) $ABVX and said: Abivax (ABVX, OW, $110 to $170 Base Case Range, Current Price ~$120), Approaching Ph3 Maintenance Data in UC: $JNJ - $PTGX TEVA ROIV - RHHBY SYRE ABBV TAK PFE BMY LLY Here's what else Morgan Stanley had to say: https://x.com/Quantumup1/status/2047053518503092554?s=20
0 · Reply
IN0V8
IN0V8 Apr. 15 at 4:27 PM
$PTGX Buy Truist Securities raises PT to $121 from $110
0 · Reply
Quantumup
Quantumup Apr. 15 at 12:33 PM
H.C. Wainwright reiterated $ALMS Buy; $25 after H.C. Wainwright's 4th Annual Inflammatory Skin Disease Virtual Conference. $JNJ - $PTGX ORKA TAK BMY ABBV NVS LLY H.C. Wainwright said in its note: Per our Inflammatory Skin Disease Conference yesterday, our most important takeaways from the fireside chat with Alumis management were as follows: (1) envu may be the strongest oral TYK2, given the baseline characteristics and comparability between envu trials, (2) response may still deepen beyond Week 24, (3) twice-daily (BID) dosing is expected to be a temporary launch format (with QD on the way), and (4) differentiators from competition could be itch relief, quality of life, and prescribing simplicity (with simplicity strategy yet to be unveiled). We reiterate our Buy rating and 12-month price target of $25.
0 · Reply
STOCKINSIGHT69
STOCKINSIGHT69 Apr. 10 at 12:43 PM
$JNJ $PTGX Bofa inaugural Doctor day KOL expects JNJ’s recently launched Icotyde (Ico; oral IL-23) to be the best oral option available in psoriasis and believes everyone on Otezla/Sotyktu (in theory) should get switched to Ico (all else equal), thus expects a fair amount of usage.
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WallStWireAds
WallStWireAds Apr. 9 at 11:40 AM
$ENTX New Cap Notes Report: Bones of a Bet: Why the Smart Money That Backed ChemoCentryx, Blueprint and Protagonist Just Put Its Chips on Entera Bio https://capnotes.beehiiv.com/p/bones-of-a-bet-why-the-smart-money-that-backed-chemocentryx-blueprint-and-protagonist-just-put-its-c The fund that backed ChemoCentryx ($3.7B exit), Blueprint Medicines ($9.1B exit) and Protagonist Therapeutics ($5.9B+ valuation) just invested in Entera Bio – a $54 million company developing the world’s first oral bone-building pill, with Phase 3 on the launchpad and an FDA response due in weeks. $CCXI $BPMC $PTGX $VKTX
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SuperGreenToday
SuperGreenToday Apr. 8 at 2:45 PM
$PTGX Share Price: $104.75 Contract Selected: Oct 16, 2026 $105 Calls Buy Zone: $10.62 – $13.12 Target Zone: $19.51 – $23.85 Potential Upside: 73% ROI Time to Expiration: 190 Days | Updates via https://fxcapta.com/stockinfo/
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OfficialStocktwitsUser
OfficialStocktwitsUser Apr. 8 at 12:46 PM
$PTGX RSI: 61.24, MACD: 3.4472 Vol: 3.53, MA20: 99.83, MA50: 91.40 🟢 BUY - Uptrend + healthy RSI 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
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Quantumup
Quantumup Apr. 6 at 8:19 PM
Clear Street⬆️ $PTGX's PT to $116 from $104 and reiterated at a Buy rating. $JNJ $ABBV BMY ALMS ABVX TAK Clear Street said in its note: We come away incrementally more constructive following our post-AAD management meeting and raise our PT to $116 from $104, with ICOTYDE further de-risking as a differentiated oral IL-23 and emerging as a potential best-in-class option in chronic indications. Its clean label (no TB test), placebo-like safety, and SKYRIZI-like, highly competitive efficacy (vs. SOTYKTU and potentially STELARA) can credibly position ICOTYDE as a preferred choice for long-term (maintenance) use, where oral convenience should further accelerate adoption. Accordingly, we increase our PsO peak penetration assumption to 18% from 15%, driving our PT revision.
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Night_Owl_Biotech
Night_Owl_Biotech Apr. 3 at 1:40 AM
Our records indicate $PTGX trades at the highest multiple of 5 & 10-year analyst consensus of all commercial-stage bios with market caps over $1B (oncology & non). This is not investment advice. We have no idea if this is a meaningful data point to understand PTGX's value proposition and/or investment thesis. $LGND trades at the 2nd highest (but LGND's gross margin was 95% in FY25). It is worth noting $ZYME is a close third. ZYME's revenues (at least near-term) are sourced via royalties (100% gross margin) just like PTGX For perspective, the attachment compares PTGX's multiples to the 5 we posted last night (appearing on the top). These are traditional comm'l-stage bios responsible for manufacturing & selling their therapies. These are not peers (outside of being biopharmas). $XBI $IBB
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notreload_ai
notreload_ai Mar. 30 at 4:57 PM
$ALMS , $PTGX ... Alumis shares plunged after strong Phase 3 psoriasis data for envudeucitinib. HC Wainwright cuts price target to $25 citing rising competition. https://notreload.xyz/alumis-stock-crashes-in-classic-sell-the-news-after-strong-phase-3-psoriasis-data/
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Quantumup
Quantumup Mar. 24 at 1:27 PM
Truist reiterated $ABVX Buy; $140, and said—Recent & Final DSMB Update Clears Way for the Key Ph. III Maintenance UC Readout in Late 2Q26 $JNJ - $PTGX TEVA ROIV - RHHBY SYRE ABBV TAK PFE BMY LLY Truist added—ABVX's 4Q25 planned EPS update (consistent with their financial calendar set in Jan-25) supports continued clinical execution of obefazimod in IBD. The ulcerative colitis ABTECT Ph. III maintenance topline in late 2Q26E remains on track, helped by a green light from the March 18th DSMB meeting with nearly 90% of patients having completed the 44-week maintenance trial. With new leadership adds and capability building and a fuller view of obefazimod's clinical profile from ECCO (including Crohn's disease ph.llb program* eyeing a 4Q26E topline), we continue to see a robust opportunity awaiting obe'. We update our model for the Q and reiterate our Buy rating and $140 PT.
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Quantumup
Quantumup Mar. 24 at 11:43 AM
Citizens reiterated $ABVX Market Outperform; $131, and said:::Top-line results from the ongoing Phase 3 ABTECT-UC trial are anticipated in late-2Q26. $JNJ - $PTGX TEVA ROIV - RHHBY SYRE ABBV TAK PFE BMY LLY Citizens added:::We continue to believe in the potential for positive results, supported by the robust responder rate demonstrated in the induction phase, as well as the Phase 2b long-term extension results. The recently completed (March 18, 2026) safety review conducted by the independent Data Safety Monitoring Board (DSMB), which found no new safety signals, reinforces our confidence in the candidate's clean safety profile. We view this as especially notable given this most recent DSMB assessment included all randomized patients in the Phase 3 maintenance trial, with nearly 90% of patients having completed the 44-week trial.
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Cache_Money
Cache_Money Mar. 19 at 10:22 PM
$PTGX I believe we’ll see more accumulation in the coming weeks. An interesting thing to note about this stock is that it has not had great visibility for retail - most of the interest has been from institutions.
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TheWolfOfSanFran
TheWolfOfSanFran Mar. 19 at 7:01 PM
$PTGX to the moon 🌙 with $JNJ
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