Market Cap 7.62B
Revenue (ttm) 0.00
Net Income (ttm) -155.20M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 973,900
Avg Vol 1,362,842
Day's Range N/A - N/A
Shares Out 87.94M
Stochastic %K 24%
Beta 3.02
Analysts Strong Sell
Price Target $100.00

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necros...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
Building 23, Suite 105 221 Crescent Street, Waltham, United States
oaksapollo
oaksapollo Jul. 2 at 3:57 AM
$SYRE This type of incremental innovation will never amount to anything. YTE is in the public domain. Literally anyone can do what they're doing. If it were worth doing, believe me, the companies who own the innovative molecules would be making YTE versions (and maybe they are, we just don't know it yet). They would have a massive edge in terms of understanding PK/PD of the YTE version, and could possibly go from phase 1 straight to phase 3. How funny would that be if we find out that Merck or Roche is already moving on a YTE TL1A phase 3? SYRE would go to $5.
1 · Reply
Cache_Money
Cache_Money Jun. 28 at 12:19 AM
$SYRE I could see this dipping since we’re only getting monotherapy readouts for SKYLINE this year but I believe this company is on the right track with subcu antibody co-formulations.
0 · Reply
TopTierNewswire
TopTierNewswire Jun. 26 at 6:57 PM
$SYRE flagged as short candidate by Top Tier Newswire AI for massive insider sales.
0 · Reply
Cache_Money
Cache_Money Jun. 25 at 3:42 AM
$SYRE Sold some shares in the high 90’s and buying back on this pullback
0 · Reply
isEEu28
isEEu28 Jun. 24 at 7:59 PM
$SYRE 👀 📈
0 · Reply
OpenOutcrier
OpenOutcrier Jun. 24 at 12:25 PM
$SYRE (-14.2% pre) SYRE (NASDAQ) Form 144: 20,000 RSUs listed; insider sold 80,000 on 05/08/2026 https://ooc.bz/l/106029
0 · Reply
TopTierNewswire
TopTierNewswire Jun. 24 at 3:09 AM
$SYRE director dumped 85% of their position!
1 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jun. 22 at 5:28 PM
$SYRE 25% Trim Will ride to FDA approve Wutch $APGE $ABBV
0 · Reply
JFais
JFais Jun. 22 at 2:59 PM
$SYRE $XNCR EV gap 🧐 (great discussion in Chat this AM)
0 · Reply
Pika_Capital
Pika_Capital Jun. 22 at 2:16 PM
$APGE $SYRE $ORKA absolutely WILD day for pfolio
4 · Reply
Latest News on SYRE
Spyre Therapeutics Announces Grants of Inducement Awards

Jul 2, 2026, 4:05 PM EDT - 1 day ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics files automatic mixed securities shelf

2026-06-26T20:10:16.000Z - 7 days ago

Spyre Therapeutics files automatic mixed securities shelf


Biotech ETF Index Surges 10% After Rebalance

Jun 25, 2026, 11:31 AM EDT - 9 days ago

Biotech ETF Index Surges 10% After Rebalance

ALKS APGE DFTX DYN KLRA KYMR MANE


Spyre Therapeutics Slides: Corporate presentation

Jun 2, 2026, 7:00 AM EDT - 4 weeks ago

Spyre Therapeutics Slides: Corporate presentation


Spyre Therapeutics management to meet with BTIG

2026-05-27T19:00:13.000Z - 5 weeks ago

Spyre Therapeutics management to meet with BTIG


Spyre Therapeutics Transcript: AGM 2026

May 27, 2026, 12:00 PM EDT - 5 weeks ago

Spyre Therapeutics Transcript: AGM 2026


Spyre Therapeutics price target raised to $97 from $64 at Citi

2026-05-07T08:43:33.000Z - 2 months ago

Spyre Therapeutics price target raised to $97 from $64 at Citi


Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)

2026-05-05T12:27:39.000Z - 2 months ago

Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)


Spyre Therapeutics Quarterly report: Q1 2026

May 5, 2026, 7:00 AM EDT - 2 months ago

Spyre Therapeutics Quarterly report: Q1 2026


Spyre Therapeutics Earnings release: Q1 2026

May 5, 2026, 7:00 AM EDT - 2 months ago

Spyre Therapeutics Earnings release: Q1 2026


Spyre Therapeutics 6.5M share Secondary priced at $62.00

2026-04-15T09:50:13.000Z - 2 months ago

Spyre Therapeutics 6.5M share Secondary priced at $62.00


Spyre Therapeutics price target raised to $90 from $65 at Baird

2026-04-14T11:44:26.000Z - 2 months ago

Spyre Therapeutics price target raised to $90 from $65 at Baird


Spyre Therapeutics Transcript: Study result

Apr 13, 2026, 8:00 AM EDT - 2 months ago

Spyre Therapeutics Transcript: Study result


Spyre Therapeutics Press release: Study result

Apr 13, 2026, 8:00 AM EDT - 2 months ago

Spyre Therapeutics Press release: Study result


Spyre Therapeutics Slides: Study result

Apr 13, 2026, 8:00 AM EDT - 2 months ago

Spyre Therapeutics Slides: Study result


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 3 months ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 3 months ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Earnings release: Q4 2025

Feb 19, 2026, 7:00 AM EST - 4 months ago

Spyre Therapeutics Earnings release: Q4 2025


Spyre Therapeutics Annual report: Q4 2025

Feb 19, 2026, 7:00 AM EST - 4 months ago

Spyre Therapeutics Annual report: Q4 2025


Spyre Therapeutics Registration statement: Registration Filing

Feb 19, 2026, 7:00 AM EST - 4 months ago

Spyre Therapeutics Registration statement: Registration Filing


Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 8:40 AM EST - 8 months ago

Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference


Spyre Therapeutics Slides: Corporate Presentation

Nov 9, 2025, 6:00 PM EST - 8 months ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q3 2025

Nov 4, 2025, 7:00 AM EST - 8 months ago

Spyre Therapeutics Earnings release: Q3 2025


Spyre Therapeutics Quarterly report: Q3 2025

Nov 4, 2025, 7:00 AM EST - 8 months ago

Spyre Therapeutics Quarterly report: Q3 2025


Spyre Therapeutics Earnings release: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 11 months ago

Spyre Therapeutics Earnings release: Q2 2025


Spyre Therapeutics Quarterly report: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 11 months ago

Spyre Therapeutics Quarterly report: Q2 2025


Spyre Therapeutics Transcript: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Transcript: Status Update


Spyre Therapeutics Press release: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Press release: Status Update


Spyre Therapeutics Slides: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Status Update


Spyre Therapeutics Slides: Corporate Presentation

Jun 17, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Earnings release: Q1 2025


Spyre Therapeutics Quarterly report: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Quarterly report: Q1 2025


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Earnings release: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Earnings release: Q4 2024


Spyre Therapeutics Annual report: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Annual report: Q4 2024


Spyre Therapeutics Slides: Corporate Presentation

Jan 13, 2025, 7:00 AM EST - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


oaksapollo
oaksapollo Jul. 2 at 3:57 AM
$SYRE This type of incremental innovation will never amount to anything. YTE is in the public domain. Literally anyone can do what they're doing. If it were worth doing, believe me, the companies who own the innovative molecules would be making YTE versions (and maybe they are, we just don't know it yet). They would have a massive edge in terms of understanding PK/PD of the YTE version, and could possibly go from phase 1 straight to phase 3. How funny would that be if we find out that Merck or Roche is already moving on a YTE TL1A phase 3? SYRE would go to $5.
1 · Reply
Cache_Money
Cache_Money Jun. 28 at 12:19 AM
$SYRE I could see this dipping since we’re only getting monotherapy readouts for SKYLINE this year but I believe this company is on the right track with subcu antibody co-formulations.
0 · Reply
TopTierNewswire
TopTierNewswire Jun. 26 at 6:57 PM
$SYRE flagged as short candidate by Top Tier Newswire AI for massive insider sales.
0 · Reply
Cache_Money
Cache_Money Jun. 25 at 3:42 AM
$SYRE Sold some shares in the high 90’s and buying back on this pullback
0 · Reply
isEEu28
isEEu28 Jun. 24 at 7:59 PM
$SYRE 👀 📈
0 · Reply
OpenOutcrier
OpenOutcrier Jun. 24 at 12:25 PM
$SYRE (-14.2% pre) SYRE (NASDAQ) Form 144: 20,000 RSUs listed; insider sold 80,000 on 05/08/2026 https://ooc.bz/l/106029
0 · Reply
TopTierNewswire
TopTierNewswire Jun. 24 at 3:09 AM
$SYRE director dumped 85% of their position!
1 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jun. 22 at 5:28 PM
$SYRE 25% Trim Will ride to FDA approve Wutch $APGE $ABBV
0 · Reply
JFais
JFais Jun. 22 at 2:59 PM
$SYRE $XNCR EV gap 🧐 (great discussion in Chat this AM)
0 · Reply
Pika_Capital
Pika_Capital Jun. 22 at 2:16 PM
$APGE $SYRE $ORKA absolutely WILD day for pfolio
4 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jun. 22 at 12:12 PM
$SYRE Call me Syre That new
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jun. 22 at 12:06 PM
$APGE $ABBV rumored to buy Was just about to post here today Fits my bio space, DERM, Respiratory, And now Gastro. 😭 $SYRE $ORKA
0 · Reply
Pika_Capital
Pika_Capital Jun. 21 at 4:25 PM
All 3 $ORKA $APGE $SYRE massive winners for Pika. If APGE is taken out tomorrow I expect other 2 to follow eventually.
1 · Reply
justiceforb_85
justiceforb_85 Jun. 21 at 2:15 AM
$SYRE wondering what the thesis is for their TL1A asset-- mainly dosing interval, or potency?
0 · Reply
outlawinvestor1
outlawinvestor1 Jun. 19 at 9:59 PM
$APGE 💥🥳 $SYRE $ORKA $JBIO $CBIO https://www.reuters.com/business/healthcare-pharmaceuticals/abbvie-nears-11-billion-deal-apogee-therapeutics-ft-reports-2026-06-19/
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jun. 17 at 7:09 PM
$SYRE New Highs and $ARWR $AMRX in reach Eyeing $AXSM
0 · Reply
DrewskiC99
DrewskiC99 Jun. 17 at 3:29 PM
$SYRE the market is wrong here
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jun. 16 at 7:24 PM
$SYRE That New 🚬
0 · Reply
BreakoutsHappen
BreakoutsHappen Jun. 15 at 9:05 AM
0 · Reply
oaksapollo
oaksapollo Jun. 13 at 1:56 AM
$SYRE $7B cap, absolute insanity. Years from commercialization, loaded with clinical execution risk, fierce competition, and sure to dilute significantly between now and any potential approval. No idea why anyone wants to own this. If options ever become more liquid I will be making bearish bets on a regular basis.
2 · Reply