Market Cap 9.20B
Revenue (ttm) 0.00
Net Income (ttm) -155.20M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 949,500
Avg Vol 1,321,814
Day's Range N/A - N/A
Shares Out 87.94M
Stochastic %K 94%
Beta 3.03
Analysts Strong Sell
Price Target $120.20

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necros...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
Building 23, Suite 105 221 Crescent Street, Waltham, United States
StockConsultant
StockConsultant Aug. 19 at 1:29 PM
$SYRE Spyre Therapeutics stock, watch for a narrow range breakout at https://www.stockconsultant.com/?SYRE Breakout trade WATCH for possible breakout above 108.14 Target: 126.14, 17% Stop: 101.31 Loss: 6% P/L ratio: 2.8 : 1 - Good BULLISH [Timing] Strong bullish 3 day candlestick pattern. [Timing] Average bullish 1 day moneyflow [Timing] breakout watch above 108.14, no resistance in area just above. BEARISH [Positioning] Intermediate trend possibly bearish, Uptrend turned sideways, may continue or pullback. [Positioning] at resistance
0 · Reply
AXLFI_HQ
AXLFI_HQ Aug. 19 at 12:28 PM
The most recent New High signal on $SYRE triggered on 2026-08-18. The expected return for the selected horizon is +33.79% with a historical profit probability of +73.33%. Learn more: https://axlfi.com/factor-analysis?symbol=SYRE&factor=new_high&timeframe=daily
0 · Reply
GordoHLYK13
GordoHLYK13 Aug. 19 at 11:25 AM
$IGC $IMNM $INTS $NUVB $SYRE https://youtu.be/ger_p3eVdQ0?is=okQ_sPh7UWGqutbj
1 · Reply
GordoHLYK13
GordoHLYK13 Aug. 19 at 11:24 AM
$IGC The setup is getting very interesting. Phase 2 CALMA is nearing completion, enrollment has already exceeded the original target, and Q4 2026 topline results are the major catalyst. While the market is focused on the noise, I’m focused on the execution, the clinical catalyst, and the potential re-rating if IGC-AD1 delivers meaningful results. Add the AI/data platform, regulatory preparation, insider debt conversion, and a relatively small valuation—and the risk/reward starts getting interesting. This isn’t about hype; it’s about the catalyst ahead. If Phase 2 hits, $IGC could go from overlooked micro-cap to a serious biotech story very quickly. Shorts may be watching the chart, but bulls are watching the data 🚀🔥 Management has put $1.5 million on the line, showing strong confidence and alignment heading into the catalyst $NUVB $SYRE * $IMNM * $INTS Updates released one day ago https://youtu.be/ger_p3eVdQ0?is=L8PItIi_MIslLlvG
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Aug. 18 at 4:58 PM
Call me $SYRE
1 · Reply
FennickTradings
FennickTradings Aug. 18 at 2:16 PM
$SYRE got my dividend, around 2k 🔥
0 · Reply
nbkihy8
nbkihy8 Aug. 15 at 11:44 PM
$SYRE Can anyone fill me in on the details of the dividend that triggered?
1 · Reply
SoxFan666
SoxFan666 Aug. 15 at 12:29 AM
$SYRE just got 10k divy 🙏🙏🙏🙏
2 · Reply
Quantumup
Quantumup Aug. 12 at 3:42 PM
BTIG Sees Positive Readthroughs to $JBIO (Buy-$77), $ORKA (Buy-$151), $SYRE (Buy-$132), CBIO (NR), and DMRA (NR) after ABBV (NR) & APGE (⬇️to Neutral) M&A. *Notes APGE as the First Successful Partnered Exit from Paragon Labs/Fairmount of the Group Mentioned Above. Here's what BTIG said in its note to investors: https://x.com/Quantumup1/status/2087565029822320875?s=20
0 · Reply
JFais
JFais Aug. 12 at 2:51 PM
$XNCR (L) Beauty of a chart, curling up nicely Could argue $1.3B EV = ENPP3 in RCC alone, getting pipeline for free Prior deal comps in TL1A space should be reconsidered in light of $MRK's phase 2b success in HS Also, $SYRE with upcoming readouts in RA, PsA & axSpa as well
0 · Reply
Latest News on SYRE
Spyre Therapeutics Announces Grants of Inducement Awards

Aug 7, 2026, 4:05 PM EDT - 11 days ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics reports Q2 EPS (36c), consensus (75c)

2026-08-04T20:21:51.000Z - 14 days ago

Spyre Therapeutics reports Q2 EPS (36c), consensus (75c)


Spyre Therapeutics Quarterly report: Q2 2026

Aug 4, 2026, 7:00 AM EDT - 15 days ago

Spyre Therapeutics Quarterly report: Q2 2026


Spyre Therapeutics Earnings release: Q2 2026

Aug 4, 2026, 7:00 AM EDT - 15 days ago

Spyre Therapeutics Earnings release: Q2 2026


Spyre Therapeutics files automatic mixed securities shelf

2026-06-26T20:10:16.000Z - 7 weeks ago

Spyre Therapeutics files automatic mixed securities shelf


Biotech ETF Index Surges 10% After Rebalance

Jun 25, 2026, 11:31 AM EDT - 7 weeks ago

Biotech ETF Index Surges 10% After Rebalance

ALKS APGE DFTX DYN KLRA KYMR MANE


Spyre Therapeutics price target raised to $112 from $98 at BTIG

2026-06-15T19:40:28.000Z - 2 months ago

Spyre Therapeutics price target raised to $112 from $98 at BTIG


Spyre Therapeutics Slides: Corporate presentation

Jun 2, 2026, 7:00 AM EDT - 2 months ago

Spyre Therapeutics Slides: Corporate presentation


Spyre Therapeutics management to meet with BTIG

2026-05-27T19:00:13.000Z - 2 months ago

Spyre Therapeutics management to meet with BTIG


Spyre Therapeutics Transcript: AGM 2026

May 27, 2026, 12:00 PM EDT - 2 months ago

Spyre Therapeutics Transcript: AGM 2026


Spyre Therapeutics price target raised to $97 from $64 at Citi

2026-05-07T08:43:33.000Z - 3 months ago

Spyre Therapeutics price target raised to $97 from $64 at Citi


Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)

2026-05-05T12:27:39.000Z - 3 months ago

Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)


Spyre Therapeutics Quarterly report: Q1 2026

May 5, 2026, 7:00 AM EDT - 3 months ago

Spyre Therapeutics Quarterly report: Q1 2026


Spyre Therapeutics Earnings release: Q1 2026

May 5, 2026, 7:00 AM EDT - 3 months ago

Spyre Therapeutics Earnings release: Q1 2026


Spyre Therapeutics Transcript: Study result

Apr 13, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Transcript: Study result


Spyre Therapeutics Press release: Study result

Apr 13, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Press release: Study result


Spyre Therapeutics Slides: Study result

Apr 13, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Slides: Study result


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Proxy statement: Proxy filing

Apr 10, 2026, 8:00 AM EDT - 4 months ago

Spyre Therapeutics Proxy statement: Proxy filing


Spyre Therapeutics Earnings release: Q4 2025

Feb 19, 2026, 7:00 AM EST - 6 months ago

Spyre Therapeutics Earnings release: Q4 2025


Spyre Therapeutics Annual report: Q4 2025

Feb 19, 2026, 7:00 AM EST - 6 months ago

Spyre Therapeutics Annual report: Q4 2025


Spyre Therapeutics Registration statement: Registration Filing

Feb 19, 2026, 7:00 AM EST - 6 months ago

Spyre Therapeutics Registration statement: Registration Filing


Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 8:40 AM EST - 10 months ago

Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference


Spyre Therapeutics Slides: Corporate Presentation

Nov 9, 2025, 6:00 PM EST - 10 months ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q3 2025

Nov 4, 2025, 7:00 AM EST - 10 months ago

Spyre Therapeutics Earnings release: Q3 2025


Spyre Therapeutics Quarterly report: Q3 2025

Nov 4, 2025, 7:00 AM EST - 10 months ago

Spyre Therapeutics Quarterly report: Q3 2025


Spyre Therapeutics Earnings release: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Earnings release: Q2 2025


Spyre Therapeutics Quarterly report: Q2 2025

Aug 5, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Quarterly report: Q2 2025


Spyre Therapeutics Transcript: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Transcript: Status Update


Spyre Therapeutics Press release: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Press release: Status Update


Spyre Therapeutics Slides: Status Update

Jun 17, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Status Update


Spyre Therapeutics Slides: Corporate Presentation

Jun 17, 2025, 7:00 AM EDT - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Earnings release: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Earnings release: Q1 2025


Spyre Therapeutics Quarterly report: Q1 2025

May 8, 2025, 4:00 PM EDT - 1 year ago

Spyre Therapeutics Quarterly report: Q1 2025


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Proxy statement: Proxy Filing

Apr 14, 2025, 8:00 AM EDT - 1 year ago

Spyre Therapeutics Proxy statement: Proxy Filing


Spyre Therapeutics Earnings release: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Earnings release: Q4 2024


Spyre Therapeutics Annual report: Q4 2024

Feb 27, 2025, 9:30 AM EST - 1 year ago

Spyre Therapeutics Annual report: Q4 2024


Spyre Therapeutics Slides: Corporate Presentation

Jan 13, 2025, 7:00 AM EST - 1 year ago

Spyre Therapeutics Slides: Corporate Presentation


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


StockConsultant
StockConsultant Aug. 19 at 1:29 PM
$SYRE Spyre Therapeutics stock, watch for a narrow range breakout at https://www.stockconsultant.com/?SYRE Breakout trade WATCH for possible breakout above 108.14 Target: 126.14, 17% Stop: 101.31 Loss: 6% P/L ratio: 2.8 : 1 - Good BULLISH [Timing] Strong bullish 3 day candlestick pattern. [Timing] Average bullish 1 day moneyflow [Timing] breakout watch above 108.14, no resistance in area just above. BEARISH [Positioning] Intermediate trend possibly bearish, Uptrend turned sideways, may continue or pullback. [Positioning] at resistance
0 · Reply
AXLFI_HQ
AXLFI_HQ Aug. 19 at 12:28 PM
The most recent New High signal on $SYRE triggered on 2026-08-18. The expected return for the selected horizon is +33.79% with a historical profit probability of +73.33%. Learn more: https://axlfi.com/factor-analysis?symbol=SYRE&factor=new_high&timeframe=daily
0 · Reply
GordoHLYK13
GordoHLYK13 Aug. 19 at 11:25 AM
$IGC $IMNM $INTS $NUVB $SYRE https://youtu.be/ger_p3eVdQ0?is=okQ_sPh7UWGqutbj
1 · Reply
GordoHLYK13
GordoHLYK13 Aug. 19 at 11:24 AM
$IGC The setup is getting very interesting. Phase 2 CALMA is nearing completion, enrollment has already exceeded the original target, and Q4 2026 topline results are the major catalyst. While the market is focused on the noise, I’m focused on the execution, the clinical catalyst, and the potential re-rating if IGC-AD1 delivers meaningful results. Add the AI/data platform, regulatory preparation, insider debt conversion, and a relatively small valuation—and the risk/reward starts getting interesting. This isn’t about hype; it’s about the catalyst ahead. If Phase 2 hits, $IGC could go from overlooked micro-cap to a serious biotech story very quickly. Shorts may be watching the chart, but bulls are watching the data 🚀🔥 Management has put $1.5 million on the line, showing strong confidence and alignment heading into the catalyst $NUVB $SYRE * $IMNM * $INTS Updates released one day ago https://youtu.be/ger_p3eVdQ0?is=L8PItIi_MIslLlvG
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Aug. 18 at 4:58 PM
Call me $SYRE
1 · Reply
FennickTradings
FennickTradings Aug. 18 at 2:16 PM
$SYRE got my dividend, around 2k 🔥
0 · Reply
nbkihy8
nbkihy8 Aug. 15 at 11:44 PM
$SYRE Can anyone fill me in on the details of the dividend that triggered?
1 · Reply
SoxFan666
SoxFan666 Aug. 15 at 12:29 AM
$SYRE just got 10k divy 🙏🙏🙏🙏
2 · Reply
Quantumup
Quantumup Aug. 12 at 3:42 PM
BTIG Sees Positive Readthroughs to $JBIO (Buy-$77), $ORKA (Buy-$151), $SYRE (Buy-$132), CBIO (NR), and DMRA (NR) after ABBV (NR) & APGE (⬇️to Neutral) M&A. *Notes APGE as the First Successful Partnered Exit from Paragon Labs/Fairmount of the Group Mentioned Above. Here's what BTIG said in its note to investors: https://x.com/Quantumup1/status/2087565029822320875?s=20
0 · Reply
JFais
JFais Aug. 12 at 2:51 PM
$XNCR (L) Beauty of a chart, curling up nicely Could argue $1.3B EV = ENPP3 in RCC alone, getting pipeline for free Prior deal comps in TL1A space should be reconsidered in light of $MRK's phase 2b success in HS Also, $SYRE with upcoming readouts in RA, PsA & axSpa as well
0 · Reply
anachartanalyst
anachartanalyst Aug. 11 at 11:01 AM
$SYRE https://anachart.com/wp-content/uploads/2026/08/1786446071_soc-img.jpg
0 · Reply
Pika_Capital
Pika_Capital Aug. 10 at 3:27 PM
$ORKA $SYRE they will most likely be gone too for a nice premium after $APGE riding it through
1 · Reply
Cache_Money
Cache_Money Aug. 8 at 4:23 PM
$SYRE SKYWAY’s RA readout is coming up. Spyre’s preclinical CIA data shows SPY072 had neck-and-neck efficacy with an anti-TNF. If the human results are similar here is how this could be a win: -Less frequent dosing than current TNFs and better safety profile than JAKs. -If targeting TL1A isn’t better than TNF overall but it is effective in TNF/JAK non-responders, Spyre would successfully capture the multi-billion dollar treatment-refractory market. -For the pauci-immune RA patient subset, the major pathogenic cell types are not immune cells but fibroblast-like synoviocytes, on which TL1A binds to its non-canonical receptor TNFR2, producing massive amounts of tissue-destroying IL-6. Because of this, SPY072 may have particular efficacy in this pathotype. These patients are also more likely to be refractory to advanced treatment as mentioned above. Preclinical data doesn’t always translate but there are strong scientific reasons to be excited for this readout.
2 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Aug. 7 at 2:59 PM
$SYRE The other day 130 at Gugg Still long
0 · Reply
CDMO
CDMO Aug. 4 at 9:07 PM
$SYRE hot
0 · Reply
DrewskiC99
DrewskiC99 Aug. 4 at 7:34 PM
$SYRE crazy over valued
0 · Reply
ICEMAN_ALERT
ICEMAN_ALERT Aug. 1 at 9:51 PM
​If upcoming trial data holds, the IBD space is primed for major shifts over the next decade. $PTGX and $JNJ could dominate first-line treatment as oral IL-23s replace injectables. $SYRE stands out as a prime buyout candidate through combo therapies and strong Phase 2 data (40% remission rate), while $AGMB targets high-unmet needs in fibrostenosing Crohn's.
1 · Reply
Cache_Money
Cache_Money Aug. 1 at 8:37 PM
Here is how the IBD landscape could evolve over the next decade, assuming strong upcoming trial data for all players listed: -$PTGX’s and $JNJ’s Icotrokinra becoming the frontline standard of care for IBD. IL-23 pathway inhibitors already have displaced TNFi’s due to unprecedented safety and an oral IL-23 will capture a large market share from injectables as we have already seen in PsO. -$SYRE ’s combo therapies step in for a significant percentage of monotherapy non-responders. The TL1A/IL-23 combo is in phase 2 already and Spyre also has a half-life extended alpha 4 beta 7 antibody with a 40% (!) clinical remission rate on its own that also has combo potential. All three targets have an excellent safety profile. Spyre is a prime buyout candidate, especially given strong phase 2 SKYLINE results in 2026 and 2027. -$AGMB’s ALK5i used in fibrostenosing Crohn’s Disease, a highly unmet medical need. Patients will remain on immune pathway inhibitors like the ones above.
0 · Reply
notreload_ai
notreload_ai Jul. 28 at 1:25 PM
Wolfe Research cuts $SYRE from Outperform to Peer Perform, citing fair valuation ($96$113) and weaker Q3 catalysts. https://notreload.xyz/xy/wolfe-research-downgrades-syre-to-peer-perform-on-valuation-concerns/
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Jul. 24 at 2:09 PM
$SYRE God candles
0 · Reply
Cache_Money
Cache_Money Jul. 22 at 2:54 AM
$SYRE The upcoming reaction stock to the monotherapy readouts makes me nervous. Much more confident in the SKYLINE IL-23 + TL1A data next year but did lock in some gains today.
1 · Reply
Luckyizme
Luckyizme Jul. 20 at 10:48 AM
$SYRE A dip back to $86 would be nice. Not complaining tho.
0 · Reply