Market Cap 6.64B
Revenue (ttm) 0.00
Net Income (ttm) -155.20M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 1,760,500
Avg Vol 1,148,886
Day's Range N/A - N/A
Shares Out 86.84M
Stochastic %K 68%
Beta 3.12
Analysts Strong Sell
Price Target $94.13

Company Profile

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necros...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 651 5940
Address:
Building 23, Suite 105 221 Crescent Street, Waltham, United States
oaksapollo
oaksapollo May. 12 at 3:46 AM
$SYRE this is the most absurd valuation in biotech right now. Anyone can use YTE and do what they’re doing.
1 · Reply
chking09
chking09 May. 11 at 5:28 PM
$SYRE breakout?
0 · Reply
Quantumup
Quantumup May. 6 at 11:12 AM
Stifel y'day⬆️ $SYRE's PT to $107 (was $92), reit'd at Buy/said: Following best-in-class UC PoC data for SPY001 (α4β7), SYRE is well-positioned heading into additional PoC cohorts for SPY002 (TL1A) and SPY003 (IL-23p19) in mid-year/3Q26. $JNJ TAK APGE ABVX $ABBV Here's what else Stifel had to say: https://x.com/Quantumup1/status/2051982840607215753?s=20
0 · Reply
d_risk
d_risk May. 5 at 2:55 PM
$SYRE - Spyre Therapeutics Inc - 10Q - Updated Risk Factors 🚨 Peer Alert: Risk-factor words are +208.0% above peer average (36,855 vs 11,964 across 652 peers). SYRE’s 10-Q sharpens its downside: survival now explicitly hinges on new capital despite a large cash balance; it doubles down on going-concern, perpetual-loss, and no-revenue risks; concentrates dependence on four core programs and complex drug/device, biologics and CMC hurdles; and materially expands regulatory, IP, manufacturing, AI, talent, pricing, geopolitical and control‑weakness risks that could dilute shareholders, delay approvals and cripple commercialization. 🟢 Added 🟠 Removed https://d-risk.ai/SYRE/10-Q/2026-05-05
0 · Reply
Merlintrader
Merlintrader Apr. 30 at 11:10 PM
$SYRE Spyre Therapeutics 2026 (Nasdaq: $SYRE): When Great Clinical Data Matter More Than Promises https://www.merlintrader.com/spyre-therapeutics-may2026-deepdive/
0 · Reply
draketdot
draketdot Apr. 30 at 10:19 PM
$SYRE 33% increase incoming?
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Apr. 30 at 7:49 PM
$SYRE RSI: 77.96, MACD: 6.7487 Vol: 9.71, MA20: 64.26, MA50: 51.55 ⚪ HOLD - Sideways 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
FennickTradings
FennickTradings Apr. 30 at 1:19 PM
$SYRE enough cash for cvr dividend payout😅
0 · Reply
RunnerSignals
RunnerSignals Apr. 29 at 8:10 PM
market warriors $TENB $HUM $CHGG $BIIB $SYRE reversed from red to strong green closes with 6–12% intraday swings and volume 1.2x–1.6x avg
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 29 at 2:39 PM
1 · Reply
Latest News on SYRE
Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)

2026-05-05T12:27:39.000Z - 8 days ago

Spyre Therapeutics reports Q1 EPS (74c), consensus (65c)


Spyre Therapeutics Announces Grants of Inducement Awards

May 1, 2026, 4:28 PM EDT - 11 days ago

Spyre Therapeutics Announces Grants of Inducement Awards


Spyre Therapeutics 6.5M share Secondary priced at $62.00

2026-04-15T09:50:13.000Z - 4 weeks ago

Spyre Therapeutics 6.5M share Secondary priced at $62.00


Spyre Therapeutics announces $300M offering of common stock

2026-04-13T20:50:45.000Z - 4 weeks ago

Spyre Therapeutics announces $300M offering of common stock


Spyre Therapeutics Transcript: Study result

Apr 13, 2026, 8:00 AM EDT - 4 weeks ago

Spyre Therapeutics Transcript: Study result


Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference

Nov 11, 2025, 8:40 AM EST - 6 months ago

Spyre Therapeutics Transcript: Stifel 2025 Healthcare Conference


Spyre Therapeutics Transcript: Status Update

Jun 17, 2025, 8:00 AM EDT - 11 months ago

Spyre Therapeutics Transcript: Status Update


Spyre Therapeutics Added to the Nasdaq Biotechnology Index

Dec 18, 2024, 8:00 AM EST - 1 year ago

Spyre Therapeutics Added to the Nasdaq Biotechnology Index


oaksapollo
oaksapollo May. 12 at 3:46 AM
$SYRE this is the most absurd valuation in biotech right now. Anyone can use YTE and do what they’re doing.
1 · Reply
chking09
chking09 May. 11 at 5:28 PM
$SYRE breakout?
0 · Reply
Quantumup
Quantumup May. 6 at 11:12 AM
Stifel y'day⬆️ $SYRE's PT to $107 (was $92), reit'd at Buy/said: Following best-in-class UC PoC data for SPY001 (α4β7), SYRE is well-positioned heading into additional PoC cohorts for SPY002 (TL1A) and SPY003 (IL-23p19) in mid-year/3Q26. $JNJ TAK APGE ABVX $ABBV Here's what else Stifel had to say: https://x.com/Quantumup1/status/2051982840607215753?s=20
0 · Reply
d_risk
d_risk May. 5 at 2:55 PM
$SYRE - Spyre Therapeutics Inc - 10Q - Updated Risk Factors 🚨 Peer Alert: Risk-factor words are +208.0% above peer average (36,855 vs 11,964 across 652 peers). SYRE’s 10-Q sharpens its downside: survival now explicitly hinges on new capital despite a large cash balance; it doubles down on going-concern, perpetual-loss, and no-revenue risks; concentrates dependence on four core programs and complex drug/device, biologics and CMC hurdles; and materially expands regulatory, IP, manufacturing, AI, talent, pricing, geopolitical and control‑weakness risks that could dilute shareholders, delay approvals and cripple commercialization. 🟢 Added 🟠 Removed https://d-risk.ai/SYRE/10-Q/2026-05-05
0 · Reply
Merlintrader
Merlintrader Apr. 30 at 11:10 PM
$SYRE Spyre Therapeutics 2026 (Nasdaq: $SYRE): When Great Clinical Data Matter More Than Promises https://www.merlintrader.com/spyre-therapeutics-may2026-deepdive/
0 · Reply
draketdot
draketdot Apr. 30 at 10:19 PM
$SYRE 33% increase incoming?
0 · Reply
OfficialStocktwitsUser
OfficialStocktwitsUser Apr. 30 at 7:49 PM
$SYRE RSI: 77.96, MACD: 6.7487 Vol: 9.71, MA20: 64.26, MA50: 51.55 ⚪ HOLD - Sideways 👉 https://quantumstockalerts.com Disclaimer: I am not a financial advisor. This post reflects personal analysis and opinions only. Please do your own research before investing or trading.
0 · Reply
FennickTradings
FennickTradings Apr. 30 at 1:19 PM
$SYRE enough cash for cvr dividend payout😅
0 · Reply
RunnerSignals
RunnerSignals Apr. 29 at 8:10 PM
market warriors $TENB $HUM $CHGG $BIIB $SYRE reversed from red to strong green closes with 6–12% intraday swings and volume 1.2x–1.6x avg
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 29 at 2:39 PM
1 · Reply
grandefappuccino
grandefappuccino Apr. 28 at 8:49 PM
$SYRE ready to run 5/5
0 · Reply
Avocado_smash
Avocado_smash Apr. 28 at 2:43 AM
$SYRE Structure and Trend strength up>
0 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 24 at 2:18 PM
$SYRE 68.8 is your friend.
2 · Reply
NeverFadeTheOracle
NeverFadeTheOracle Apr. 23 at 6:50 PM
$SYRE Trim under 70
1 · Reply
Avocado_smash
Avocado_smash Apr. 15 at 1:11 PM
$SYRE Strong Offering! 🚀🚀🚀🚀🚀🚀🚀🚀🚀
0 · Reply
Pika_Capital
Pika_Capital Apr. 15 at 1:10 PM
$SYRE $400M raised at $62. Power move. They got tons of cash now
0 · Reply
DonCorleone77
DonCorleone77 Apr. 15 at 10:30 AM
$SYRE Spyre Therapeutics 6.5M share Secondary priced at $62.00 The deal size was increased to $403M in common stock from $300M in common stock. Jefferies, Goldman Sachs, Evercore ISI and Guggenheim acted as joint book running managers for the offering.
0 · Reply
AlertsAndNews
AlertsAndNews Apr. 15 at 2:46 AM
$SYRE offering here Spyre Therapeutics Announces Pricing of Upsized $403.0 Million Public Offering of Common Stock "today announced the pricing of its previously announced underwritten public offering of 6,500,000 shares of its common stock at a price to the public of $62.00 per share. The gross proceeds to the Company from this offering are expected to be approximately $403.0 million"
0 · Reply
Stocks_and_Stacks
Stocks_and_Stacks Apr. 14 at 4:14 AM
🚀 Bulls charging hard on April 13 amid renewed US-Iran peace talk hopes! 🐂📈 First off 😎 who’s all up late studying charts and getting ready for tomorrow? Our group just received two new banger alerts that have serious 100-200% run potential. Eyes sharp, bulls! Huge congrats to everyone riding these top 5 movers today – resilience and catalysts delivered big green! $RVMD +41% – Revolution Medicines soaring on positive new clinical trial results in oncology. $XNDU +28% – Xanadu Quantum Technologies lifting on quantum computing buzz and sector momentum. $CAR +24% – Avis Budget Group jumping amid strong rental demand and sector rotation. $SYRE +23% – Spyre Therapeutics climbing on biotech pipeline momentum. $RCT +90%+ (earlier surge) – RedCloud Holdings exploding on a major $30M Saudi licensing deal for its RAID engine. Epic day stacking wins despite the headlines, bulls… 💪 Who else is celebrating big gains? Drop your winners below. #TopMovers #BullMarket #Stocks #BangerAlerts
0 · Reply
deweyeggbert
deweyeggbert Apr. 14 at 1:47 AM
$SYRE big dilution dip coming. Institutions will use that dip to acquire shares on the cheap. I'm in with puts and maybe go long when the dust settles.
1 · Reply
mikesterz7
mikesterz7 Apr. 14 at 1:18 AM
$SYRE Spyre is looking forward to developing the drug as a single treatment, as well as in combination with its investigational antibodies SPY002 or SPY003.
0 · Reply