Aug. 17 at 4:17 PM
$TLPH
A) Enrollment is slow because it's very restrictive:
* Most arrive bleeding and could not be enrolled until bleeding had stabilized, assuming the patient is still on CRRT.
* Most patients cannot be enrolled because their Baseline ACT (Activated Clotting Time) is over 150 seconds.
* Cannot enroll liver patients, patients with coagulopathy, patients under 110 lb, patients younger than 18 or older than 80.
* Cannot enroll patients without their consent or a surrogate consent. Patient consent is hard to get because most are critically ill, unconscious, intubated or unstable. Surrogate consent is hard to get because you need a bunch of things to happen at the same time, including research personnel, nephrology and ICU agreement, acceptable laboratory results and the patient.
Continued in next message...
