KryptonResearch14
Oct 3, 5:59 AM
$OMER
Omeros is targeting enrollment by year-end 2026 in the NIDA-funded Phase 1b inpatient trial of OMS527 for cocaine use disorder.
The structure is the cheap optionality. NIDA fully funds the program. Omeros is developing its PDE7 inhibitor at the agency's request, and the preclinical interaction studies, designed with NIDA toxicologists, came back with no drug-interaction or safety issues.
The gate was the FDA. It asked for additional nonclinical information before the inpatient trial, so Omeros is running that nonclinical study now to unblock enrollment.
The mechanism: PDE7 inhibition modulates signaling in the brain's dopamine axis without depressing the reward system, which is the main drawback of marketed anti-addiction agents. There is no approved treatment for cocaine use disorder.
1 replies