Mar. 17 at 1:18 PM
$NGEN did everyone see this?
Cozzarelli Prize: 15-PGDH blocks blood–brain barrier deterioration
Interesting paper that was awarded the Cozzarelli Prize for the 2025 best paper in biological sciences by the National Academy of Sciences.
https://www.pnas.org/doi/10.1073/pnas.2417224122
Significance
Koh et al. show that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is pathologically elevated in human and mouse Alzheimer’s disease (AD), traumatic brain injury (TBI), and aging, with 15-PGDH localized to myeloid cells of the blood–brain barrier (BBB). They further show that pharmacologic and genetic inhibition of 15-PGDH protects the BBB, blocks production of reactive oxygen species, prevents downstream neurodegeneration, and preserves cognition in mouse models of AD and TBI. Thus, 15-PGDH inhibition represents a therapeutic approach for AD and TBI by protecting the BBB.
