Market Cap 153.72M
Revenue (ttm) 146.07M
Net Income (ttm) -196.04M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -134.21%
Debt to Equity Ratio -0.40
Volume 1,496,100
Avg Vol 645,378
Day's Range N/A - N/A
Shares Out 18.34M
Stochastic %K 19%
Beta 0.13
Analysts Strong Sell
Price Target $17.14

Company Profile

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for th...

Industry: Biotechnology
Sector: Healthcare
Phone: 617 658 0600
Address:
85 Wells Avenue, 2nd Floor, Suite 210, Newton, United States
HubAllianceModern
HubAllianceModern Mar. 21 at 6:30 PM
$KPTI biotech, just observing.
0 · Reply
Smellmahass
Smellmahass Mar. 21 at 12:15 PM
$KPTI Yes i checked it out. Its balanced. Its a big mover either way.
0 · Reply
celebratelife
celebratelife Mar. 20 at 8:51 PM
$KPTI Wow check out that very impressive profile! https://www.linkedin.com/in/leonard-ellman-37a06269/
0 · Reply
celebratelife
celebratelife Mar. 20 at 8:49 PM
$KPTI Thank you Professor Ellman for the comment. Good to have you here.
0 · Reply
celebratelife
celebratelife Mar. 20 at 8:19 PM
$KPTI 2 days of roller coaster, apparently together with and to help the options trades.
0 · Reply
RandomInvestor777
RandomInvestor777 Mar. 20 at 8:04 PM
$KPTI idk why this guy always turns buying puts into bullish signal lol. Anyway, options are huge and premium/IV is huge for both calls and puts. its neither bullish or bearish. its just people betting in either one side or hedging. Massive calls/puts means the readout is uncertain which it is.
1 · Reply
celebratelife
celebratelife Mar. 20 at 7:48 PM
$KPTI It seems someone spent $1,437,000 closing $10 put options expiring today and rolling it to April. And more of what seems to be opening short positions of April puts (bullish). And someone spent a ton of money buying high strike April calls: 719,700 x 3.30 + 675,700 x 2.02 (17.50 and 10 calls) and more - across the board buys at ask it seems. Also a big 166,500 x 2.20 trade of May $20 calls at ask. This does not seem like leakage of bad data to me. It's more likely manipulation of the share price to help these and other option trades. Screenprints are saved for FINRA.
0 · Reply
ReversalTrack
ReversalTrack Mar. 20 at 4:32 PM
Something is brewing on ticker JAGU 🚨🚀 One of the most explosive signals is setting up on the daily. Uranium+Rare earth play with news . War changes everything especially energy. ⚛️ Uranium = energy independence + national security Don't sleep on ticker JAGU!! $REED $CDLX $ATOS $KPTI hot looks ./1
0 · Reply
somalight
somalight Mar. 20 at 3:32 PM
$KPTI Are they dumping the day before because they’re afraid of bad news on Friday, then buying back today? 😂 Why are the shareholders here so cute?
1 · Reply
mghmd
mghmd Mar. 20 at 3:22 PM
$KPTI I am a hematologist with 45 years experience. The phase 2 was highly encouraging. There is a desperate need for improved treatment for myelofibrosis. If the drug works for myelofibrosis it has a significant opportunity in the other myeloproliferative syndromes which include polycythemia vera, chronic myelogenous leukemia and essential thrombocythemia. It is my largest biotech holding.
4 · Reply
Latest News on KPTI
Karyopharm to Participate in Baird's Biotech Discovery Series

Dec 8, 2025, 7:00 AM EST - 3 months ago

Karyopharm to Participate in Baird's Biotech Discovery Series


Karyopharm Announces 1-for-15 Reverse Stock Split

Feb 24, 2025, 8:40 AM EST - 1 year ago

Karyopharm Announces 1-for-15 Reverse Stock Split


Karyopharm to Participate at Upcoming Investor Conferences

Sep 3, 2024, 7:00 AM EDT - 1 year ago

Karyopharm to Participate at Upcoming Investor Conferences


HubAllianceModern
HubAllianceModern Mar. 21 at 6:30 PM
$KPTI biotech, just observing.
0 · Reply
Smellmahass
Smellmahass Mar. 21 at 12:15 PM
$KPTI Yes i checked it out. Its balanced. Its a big mover either way.
0 · Reply
celebratelife
celebratelife Mar. 20 at 8:51 PM
$KPTI Wow check out that very impressive profile! https://www.linkedin.com/in/leonard-ellman-37a06269/
0 · Reply
celebratelife
celebratelife Mar. 20 at 8:49 PM
$KPTI Thank you Professor Ellman for the comment. Good to have you here.
0 · Reply
celebratelife
celebratelife Mar. 20 at 8:19 PM
$KPTI 2 days of roller coaster, apparently together with and to help the options trades.
0 · Reply
RandomInvestor777
RandomInvestor777 Mar. 20 at 8:04 PM
$KPTI idk why this guy always turns buying puts into bullish signal lol. Anyway, options are huge and premium/IV is huge for both calls and puts. its neither bullish or bearish. its just people betting in either one side or hedging. Massive calls/puts means the readout is uncertain which it is.
1 · Reply
celebratelife
celebratelife Mar. 20 at 7:48 PM
$KPTI It seems someone spent $1,437,000 closing $10 put options expiring today and rolling it to April. And more of what seems to be opening short positions of April puts (bullish). And someone spent a ton of money buying high strike April calls: 719,700 x 3.30 + 675,700 x 2.02 (17.50 and 10 calls) and more - across the board buys at ask it seems. Also a big 166,500 x 2.20 trade of May $20 calls at ask. This does not seem like leakage of bad data to me. It's more likely manipulation of the share price to help these and other option trades. Screenprints are saved for FINRA.
0 · Reply
ReversalTrack
ReversalTrack Mar. 20 at 4:32 PM
Something is brewing on ticker JAGU 🚨🚀 One of the most explosive signals is setting up on the daily. Uranium+Rare earth play with news . War changes everything especially energy. ⚛️ Uranium = energy independence + national security Don't sleep on ticker JAGU!! $REED $CDLX $ATOS $KPTI hot looks ./1
0 · Reply
somalight
somalight Mar. 20 at 3:32 PM
$KPTI Are they dumping the day before because they’re afraid of bad news on Friday, then buying back today? 😂 Why are the shareholders here so cute?
1 · Reply
mghmd
mghmd Mar. 20 at 3:22 PM
$KPTI I am a hematologist with 45 years experience. The phase 2 was highly encouraging. There is a desperate need for improved treatment for myelofibrosis. If the drug works for myelofibrosis it has a significant opportunity in the other myeloproliferative syndromes which include polycythemia vera, chronic myelogenous leukemia and essential thrombocythemia. It is my largest biotech holding.
4 · Reply
topstockalerts
topstockalerts Mar. 20 at 3:20 PM
$KPTI tends to move with sentiment shifts, not constant action but can put in solid runs when it wakes up.
0 · Reply
celebratelife
celebratelife Mar. 20 at 2:22 PM
$KPTI November options are not offered.
0 · Reply
celebratelife
celebratelife Mar. 20 at 2:18 PM
$KPTI Interesting that this morning even the $20 call for today OpEx is bidding. It's for people who want to sell covered calls today but it's still bidding because after hours good news could send the stock above $20 and that's why a market maker or person is willing to buy $20 calls.
1 · Reply
laaarsas
laaarsas Mar. 20 at 7:49 AM
$KPTI I think PR today premarket with SENTRY fail
3 · Reply
celebratelife
celebratelife Mar. 20 at 5:53 AM
$KPTI Today's trades. There are 4 large buys on the 1 minute chart at volumes: 44k, 103k, 133k, 207k. Assuming no bad data, assuming no leakage by the horrible Board or by associates of the company, big assumptions given how weak and irresponsible the company's governance seems to be, who's apparently never cared for their mandate to create shareholder value -- and given we've seen a lot of games and manipulation for years - always at the benefit of shorts and scums who make money behind the scene at the cost of shareholders (we are the ATM machines for them and CEO & Board's big paychecks and bonuses for never doing anything that has translated to value for us -- and ATM machines for the scumbags who love this lousy CEO/Board) -- then theoretically today's action could be games to make these big trades go through at favorable prices -- and strategies in conjunction with option trades (e.g. perhaps reverse conversations) since average retail investor doesn't make mil$ options trades.
0 · Reply
celebratelife
celebratelife Mar. 19 at 8:48 PM
$KPTI Such a drop on strong volume is a bad sign. Or is it tomorrow's OpEx related? I'm thinking of lousy Director Deepa Pakianathan who dumped a ton of shares before the Biogen news was made public, after the company had received the news. Board's guard dog, Mike Mano tried to justify it saying she, a Board member of the company didn't know about such a news before she dumped her shares. I'm not accusing her of leaking info but just sharing that I remembered that story. The tragedy is the CEO, Richard Paulson. Shorts love and adore him - dream CEO for crooks cockroaches vultures and other enemies of shareholders. All in my opinion. https://cdn.theorg.com/116d7da8-549e-4ded-918e-7fc6fe121350_thumb.jpg
1 · Reply
celebratelife
celebratelife Mar. 19 at 8:37 PM
$KPTI March, April trades today. For the record
0 · Reply
Kinderla
Kinderla Mar. 19 at 7:28 PM
$KPTI https://www.marketbeat.com/instant-alerts/stock-traders-purchase-large-volume-of-call-options-on-karyopharm-therapeutics-nasdaqkpti-2026-03-19/
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Kinderla
Kinderla Mar. 19 at 7:27 PM
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Kinderla
Kinderla Mar. 19 at 6:25 PM
$KPTI This stock has a TipRanks score of 10. Lowest marketcap BioTech stock to have that. Also #1 ranked stock in the BioStockInfo weekly scanner. Im in! https://www.biostockinfo.com/biotech-catalyst-ai-scanner-march-wk3/
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laaarsas
laaarsas Mar. 19 at 4:12 PM
$KPTI still no data. Maybe they lost the data? Has happened before.
1 · Reply
celebratelife
celebratelife Mar. 19 at 2:47 PM
$KPTI Strange options activity. Time for FINRA to keep an eye on this. I'll have to write to my friends there.
0 · Reply