Market Cap 1.89B
Revenue (ttm) 172.35M
Net Income (ttm) -285.42M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin -165.60%
Debt to Equity Ratio 8.26
Volume 1,203,700
Avg Vol 1,614,682
Day's Range N/A - N/A
Shares Out 88.61M
Stochastic %K 38%
Beta 0.41
Analysts Strong Sell
Price Target $39.33

Company Profile

Syndax Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, develops therapies for the treatment of cancer. Its lead product candidate includes Revuforj (revumenib), a menin inhibitor for the treatment of relapsed or refractory R/R acute leukemia; and Niktimvo (axatilimab-csfr), a colony stimulating factor-1 receptor blocking antibody to treat chronic graft-versus-host disease. The company is also developing revumenib for the treatment of R/R acute myeloid leukemia (AML) with a n...

Industry: Biotechnology
Sector: Healthcare
Phone: 781 419 1400
Website: syndax.com
Address:
730 Third Avenue, 9th Floor, New York, United States
DonCorleone77
DonCorleone77 May. 13 at 11:36 AM
$SNDX Syndax price target lowered to $37 from $38 at UBS UBS lowered the firm's price target on Syndax to $37 from $38 and keeps a Buy rating on the shares.
0 · Reply
Quantumup
Quantumup May. 13 at 10:41 AM
Citizens on $KURA said, We reiterate our Market Outperform rating and price target of $24 for Kura Oncology based on a discounted EPS and revenue multiple analysis. $SNDX ABBV BMY RHHBY DSNKY PFE $RIGL Citizens added—Yesterday, Kura announced 1Q26 financial results, provided updates on the KOMZIFTI (ziftomenib, zifto) launch and discussed milestones for 2026. Of note, the registrational Phase 3 KOMET-017 trial is enrolling ahead of expectations, with the potential for top-line results for the intensive chemo combo as early as 2028. With signs pointing to a strong KOMZIFTI launch, the frontline AML trials fully funded, the FTI program progressing in the clinic, and a cash position of $580.8MM, we believe Kura shares represent an attractive investment opportunity, with ~59% downside (bear case of $4) and ~200% upside (bull case of $29).
1 · Reply
mulc
mulc May. 13 at 4:20 AM
$SNDX I was staying quiet, but i knew kura was gonna shit the bed…just tells you that excuses sndx made in general regarding q1 for entire sector were not made up out of thin air. Now how good do their revuforj result look after this bad Q1 results for kura?
1 · Reply
dgbio
dgbio May. 13 at 3:51 AM
$SNDX Frontline menin inhibitor + intensive chemo, KMT2A and NPM1, Kura vs Syndax: →CRc 93% vs 92% →MRD- 83% vs 83%, both assessed locally, Syndax does not mention methods, Kura mentions several including flow cytometry and NGS. →QTc Prolongation, Grade 3 4% vs 4% in DLT evaluable, 3% in total. I don't see how Kura can claim any superiority.
1 · Reply
Night_Owl_Biotech
Night_Owl_Biotech May. 13 at 2:58 AM
$INCY 3/31/2026 net cash/debt is 2.24X higher than $SNDX 5/12/26 market cap. INCY disclosed their risk-free interest rate on their cash at year end was 4.1%. Ignoring the obvious synergy Revuforj revenues adds to soften the Jakafi patent cliff, INCY's cash hoarde may start to become a meaningful drag on ROE & ROA. Does KURA's Q126 revenues make a INCY/SNDX transaction more or less likely? We suspect, all things considered, more likely but WTF do we know. This is not investment advice.
0 · Reply
dgbio
dgbio May. 13 at 1:55 AM
$SNDX Reading EHA abstracts. NPM1 is complex with many co-mutations occuring. This is post-hoc look on efficacy in different co-mutations. Very high CR+CRh in some. https://library.ehaweb.org/eha/2026/eha-2026/4207502/james.s.blachly.efficacy.of.revumenib.in.acute.myeloid.leukemia.harboring.html
0 · Reply
dgbio
dgbio May. 13 at 1:42 AM
$SNDX Reading EHA abstracts. This is great. R/R setting, revumenib oral combo with decitabine and venetoclax. CR/CRh of 60% vs 21-23% revumenib mono. Median DOR CR/CRh Not Reached (KMT2A) and 10 months (NPM1) vs 6 and 4 months for mono respectively. 42 pts with R/R AML were enrolled. The median age was 40 years (range, 12–82), including 5 adolescents (12%). Seventeen pts (40%) had KMT2Ar, 16 (38%) NPM1mt, and 9 (21%) NUP98r. Pts were heavily pretreated (median 2 prior lines, range 1–5); →The CR/CRh rate was 60% (25 pts), with CR in 43% (18 pts), CRh in 17% (7 pts), CRi in 10% (4 pts), CRp in 2% (1 pt), MLFS in 14% (6 pts), and PR in 2% (1 pt). →MRD negativity by MFC in responders was 64% (24/37), and 80% (20/25) in those with CR/CRh. →QTc prolongation grade ≥3 occurred in 2 pts (5%) https://library.ehaweb.org/eha/2026/eha-2026/4207483/branko.cuglievan.phase1.2studyof.theall-oral.combination.html
0 · Reply
Hawksssss
Hawksssss May. 12 at 11:48 PM
$SNDX Kura only got 6 million in sales in the second quarter after launch. Not so good. That should get rid of one of the major concerns for us
0 · Reply
dgbio
dgbio May. 12 at 10:00 PM
$SNDX Reading EHA abstracts. Frontline Revumenib + Intensive chemo. Two dose levels (DL) of revumenib were evaluated (DL1: 110 mg/220 mg ± strong CYP3A4 inhibitor [CYP3A4i]; DL2: 160 mg/270 mg ± strong CYP3A4i) in combination with cytarabine plus daunorubicin or idarubicin. KMT2Ar was detected in 92% (12/13) of pts in DL1 and 39% (7/18) in DL2; NPM1m was detected in 8% (1/13) of pts in DL1 and 56% (10/18) in DL2. →ORR was 100% (12/12) in DL1 and 92.9% (13/14) in DL2; →CRc rate was 100% (12/12) and 85.7% (12/14); →CR rate was 91.7% (11/12) and 78.6% (11/14), respectively. →MRD−CR was achieved in 100% (8/8) of tested pts in DL1 and 70.0% (7/10) in DL2. →No pt developed differentiation syndrome →Two pts in DL1 (6% of all pts) experienced any-grade QTcF prolongation (1 case of grade 3). https://library.ehaweb.org/eha/2026/eha-2026/4207477/ibrahim.aldoss.revumenib.2B.intensive.chemotherapy.for.newly.diagnosed.acute.html
0 · Reply
dgbio
dgbio May. 12 at 9:33 PM
$SNDX Reading EHA abstracts. Revumenib maintenance therapy post-transplant: median duration of treatment - 28 weeks, median RFS and OS - Not Reached, estimated OS at 12 months - 91%, discontinuation rate - 5%, QTc prolongation Grade 3 and higher - none, QTc prolongation Grade 2 - 5%. https://library.ehaweb.org/eha/2026/eha-2026/4208183/andrius.uenka.revumenib.therapy.post.hematopoietic.stem.cell.transplant.for.html
0 · Reply
Latest News on SNDX
Syndax price target lowered to $37 from $38 at UBS

2026-05-13T12:20:45.000Z - 1 hour ago

Syndax price target lowered to $37 from $38 at UBS


Syndax reports 12 Revuforj abstracts accepted for EHA

2026-05-12T18:34:41.000Z - 18 hours ago

Syndax reports 12 Revuforj abstracts accepted for EHA


Syndax price target raised to $46 from $45 at Stifel

2026-05-04T10:54:25.000Z - 9 days ago

Syndax price target raised to $46 from $45 at Stifel


Syndax price target lowered to $37 from $40 at Jefferies

2026-05-01T19:25:20.000Z - 11 days ago

Syndax price target lowered to $37 from $40 at Jefferies


Syndax price target raised to $37 from $35 at Barclays

2026-05-01T09:40:18.000Z - 12 days ago

Syndax price target raised to $37 from $35 at Barclays


Syndax Pharmaceuticals Earnings Call Transcript: Q1 2026

Apr 30, 2026, 4:30 PM EDT - 12 days ago

Syndax Pharmaceuticals Earnings Call Transcript: Q1 2026


Syndax price target raised to $34 from $28 at Goldman Sachs

2026-03-31T11:13:38.000Z - 6 weeks ago

Syndax price target raised to $34 from $28 at Goldman Sachs


Syndax price target lowered to $43 from $45 at Mizuho

2026-03-31T11:08:14.000Z - 6 weeks ago

Syndax price target lowered to $43 from $45 at Mizuho


Syndax assumed with a Buy at Jefferies

2026-03-30T13:08:09.000Z - 6 weeks ago

Syndax assumed with a Buy at Jefferies

KURA


Syndax price target raised to $45 from $33 at JPMorgan

2026-03-09T11:11:49.000Z - 2 months ago

Syndax price target raised to $45 from $33 at JPMorgan


Syndax price target raised to $57 from $51 at Citi

2026-03-02T11:59:34.000Z - 2 months ago

Syndax price target raised to $57 from $51 at Citi


Syndax reports Q4 EPS (78c), consensus (58c)

2026-02-26T21:39:29.000Z - 2 months ago

Syndax reports Q4 EPS (78c), consensus (58c)


Syndax Pharmaceuticals Earnings Call Transcript: Q4 2025

Feb 26, 2026, 4:30 PM EST - 2 months ago

Syndax Pharmaceuticals Earnings Call Transcript: Q4 2025


Syndax Announces Participation in March Investor Conferences

Feb 23, 2026, 7:00 AM EST - 2 months ago

Syndax Announces Participation in March Investor Conferences


Syndax price target raised to $28 from $27 at BofA

2026-02-03T12:36:57.000Z - 3 months ago

Syndax price target raised to $28 from $27 at BofA


Syndax announces expected milestones for 2026

2026-01-12T12:05:54.000Z - 4 months ago

Syndax announces expected milestones for 2026


Syndax Pharmaceuticals Transcript: Investor Update

Dec 8, 2025, 7:00 AM EST - 5 months ago

Syndax Pharmaceuticals Transcript: Investor Update


Syndax price target raised to $35 from $22 at Barclays

2025-11-24T11:35:26.000Z - 6 months ago

Syndax price target raised to $35 from $22 at Barclays


Syndax price target lowered to $33 from $40 at JPMorgan

2025-11-12T12:36:22.000Z - 6 months ago

Syndax price target lowered to $33 from $40 at JPMorgan


Syndax price target raised to $38 from $35 at UBS

2025-11-04T12:42:02.000Z - 6 months ago

Syndax price target raised to $38 from $35 at UBS


Syndax Pharmaceuticals Earnings Call Transcript: Q3 2025

Nov 3, 2025, 4:30 PM EST - 6 months ago

Syndax Pharmaceuticals Earnings Call Transcript: Q3 2025


Syndax Announces Participation in November Investor Conferences

Oct 30, 2025, 7:00 AM EDT - 6 months ago

Syndax Announces Participation in November Investor Conferences


Syndax Pharmaceuticals Transcript: Study Update

Oct 24, 2025, 2:30 PM EDT - 7 months ago

Syndax Pharmaceuticals Transcript: Study Update


Syndax Announces Participation in September Investor Conferences

Aug 26, 2025, 7:00 AM EDT - 9 months ago

Syndax Announces Participation in September Investor Conferences


Syndax Pharmaceuticals Earnings Call Transcript: Q2 2025

Aug 4, 2025, 4:30 PM EDT - 10 months ago

Syndax Pharmaceuticals Earnings Call Transcript: Q2 2025


Syndax Announces Participation in June Investor Conferences

May 29, 2025, 7:00 AM EDT - 1 year ago

Syndax Announces Participation in June Investor Conferences


Syndax Announces Participation in May Investor Conferences

May 8, 2025, 7:00 AM EDT - 1 year ago

Syndax Announces Participation in May Investor Conferences


Syndax Pharmaceuticals Earnings Call Transcript: Q1 2025

May 5, 2025, 4:30 PM EDT - 1 year ago

Syndax Pharmaceuticals Earnings Call Transcript: Q1 2025


Syndax Pharmaceuticals Earnings Call Transcript: Q4 2024

Mar 3, 2025, 8:00 AM EST - 1 year ago

Syndax Pharmaceuticals Earnings Call Transcript: Q4 2024


Syndax Pharmaceuticals Transcript: Status Update

Dec 9, 2024, 10:00 AM EST - 1 year ago

Syndax Pharmaceuticals Transcript: Status Update


US FDA approves Syndax's blood cancer drug

Nov 15, 2024, 6:26 PM EST - 1 year ago

US FDA approves Syndax's blood cancer drug


Syndax Pharmaceuticals Transcript: FDA Announcement

Nov 15, 2024, 6:00 PM EST - 1 year ago

Syndax Pharmaceuticals Transcript: FDA Announcement


Syndax Pharmaceuticals Earnings Call Transcript: Q3 2024

Nov 5, 2024, 4:30 PM EST - 1 year ago

Syndax Pharmaceuticals Earnings Call Transcript: Q3 2024


DonCorleone77
DonCorleone77 May. 13 at 11:36 AM
$SNDX Syndax price target lowered to $37 from $38 at UBS UBS lowered the firm's price target on Syndax to $37 from $38 and keeps a Buy rating on the shares.
0 · Reply
Quantumup
Quantumup May. 13 at 10:41 AM
Citizens on $KURA said, We reiterate our Market Outperform rating and price target of $24 for Kura Oncology based on a discounted EPS and revenue multiple analysis. $SNDX ABBV BMY RHHBY DSNKY PFE $RIGL Citizens added—Yesterday, Kura announced 1Q26 financial results, provided updates on the KOMZIFTI (ziftomenib, zifto) launch and discussed milestones for 2026. Of note, the registrational Phase 3 KOMET-017 trial is enrolling ahead of expectations, with the potential for top-line results for the intensive chemo combo as early as 2028. With signs pointing to a strong KOMZIFTI launch, the frontline AML trials fully funded, the FTI program progressing in the clinic, and a cash position of $580.8MM, we believe Kura shares represent an attractive investment opportunity, with ~59% downside (bear case of $4) and ~200% upside (bull case of $29).
1 · Reply
mulc
mulc May. 13 at 4:20 AM
$SNDX I was staying quiet, but i knew kura was gonna shit the bed…just tells you that excuses sndx made in general regarding q1 for entire sector were not made up out of thin air. Now how good do their revuforj result look after this bad Q1 results for kura?
1 · Reply
dgbio
dgbio May. 13 at 3:51 AM
$SNDX Frontline menin inhibitor + intensive chemo, KMT2A and NPM1, Kura vs Syndax: →CRc 93% vs 92% →MRD- 83% vs 83%, both assessed locally, Syndax does not mention methods, Kura mentions several including flow cytometry and NGS. →QTc Prolongation, Grade 3 4% vs 4% in DLT evaluable, 3% in total. I don't see how Kura can claim any superiority.
1 · Reply
Night_Owl_Biotech
Night_Owl_Biotech May. 13 at 2:58 AM
$INCY 3/31/2026 net cash/debt is 2.24X higher than $SNDX 5/12/26 market cap. INCY disclosed their risk-free interest rate on their cash at year end was 4.1%. Ignoring the obvious synergy Revuforj revenues adds to soften the Jakafi patent cliff, INCY's cash hoarde may start to become a meaningful drag on ROE & ROA. Does KURA's Q126 revenues make a INCY/SNDX transaction more or less likely? We suspect, all things considered, more likely but WTF do we know. This is not investment advice.
0 · Reply
dgbio
dgbio May. 13 at 1:55 AM
$SNDX Reading EHA abstracts. NPM1 is complex with many co-mutations occuring. This is post-hoc look on efficacy in different co-mutations. Very high CR+CRh in some. https://library.ehaweb.org/eha/2026/eha-2026/4207502/james.s.blachly.efficacy.of.revumenib.in.acute.myeloid.leukemia.harboring.html
0 · Reply
dgbio
dgbio May. 13 at 1:42 AM
$SNDX Reading EHA abstracts. This is great. R/R setting, revumenib oral combo with decitabine and venetoclax. CR/CRh of 60% vs 21-23% revumenib mono. Median DOR CR/CRh Not Reached (KMT2A) and 10 months (NPM1) vs 6 and 4 months for mono respectively. 42 pts with R/R AML were enrolled. The median age was 40 years (range, 12–82), including 5 adolescents (12%). Seventeen pts (40%) had KMT2Ar, 16 (38%) NPM1mt, and 9 (21%) NUP98r. Pts were heavily pretreated (median 2 prior lines, range 1–5); →The CR/CRh rate was 60% (25 pts), with CR in 43% (18 pts), CRh in 17% (7 pts), CRi in 10% (4 pts), CRp in 2% (1 pt), MLFS in 14% (6 pts), and PR in 2% (1 pt). →MRD negativity by MFC in responders was 64% (24/37), and 80% (20/25) in those with CR/CRh. →QTc prolongation grade ≥3 occurred in 2 pts (5%) https://library.ehaweb.org/eha/2026/eha-2026/4207483/branko.cuglievan.phase1.2studyof.theall-oral.combination.html
0 · Reply
Hawksssss
Hawksssss May. 12 at 11:48 PM
$SNDX Kura only got 6 million in sales in the second quarter after launch. Not so good. That should get rid of one of the major concerns for us
0 · Reply
dgbio
dgbio May. 12 at 10:00 PM
$SNDX Reading EHA abstracts. Frontline Revumenib + Intensive chemo. Two dose levels (DL) of revumenib were evaluated (DL1: 110 mg/220 mg ± strong CYP3A4 inhibitor [CYP3A4i]; DL2: 160 mg/270 mg ± strong CYP3A4i) in combination with cytarabine plus daunorubicin or idarubicin. KMT2Ar was detected in 92% (12/13) of pts in DL1 and 39% (7/18) in DL2; NPM1m was detected in 8% (1/13) of pts in DL1 and 56% (10/18) in DL2. →ORR was 100% (12/12) in DL1 and 92.9% (13/14) in DL2; →CRc rate was 100% (12/12) and 85.7% (12/14); →CR rate was 91.7% (11/12) and 78.6% (11/14), respectively. →MRD−CR was achieved in 100% (8/8) of tested pts in DL1 and 70.0% (7/10) in DL2. →No pt developed differentiation syndrome →Two pts in DL1 (6% of all pts) experienced any-grade QTcF prolongation (1 case of grade 3). https://library.ehaweb.org/eha/2026/eha-2026/4207477/ibrahim.aldoss.revumenib.2B.intensive.chemotherapy.for.newly.diagnosed.acute.html
0 · Reply
dgbio
dgbio May. 12 at 9:33 PM
$SNDX Reading EHA abstracts. Revumenib maintenance therapy post-transplant: median duration of treatment - 28 weeks, median RFS and OS - Not Reached, estimated OS at 12 months - 91%, discontinuation rate - 5%, QTc prolongation Grade 3 and higher - none, QTc prolongation Grade 2 - 5%. https://library.ehaweb.org/eha/2026/eha-2026/4208183/andrius.uenka.revumenib.therapy.post.hematopoietic.stem.cell.transplant.for.html
0 · Reply
dgbio
dgbio May. 12 at 9:16 PM
$SNDX Reading EHA abstracts: 'We identify a previously unrecognized mechanism of MENIN inhibitor resistance in KMT2A::MLLT3 AML mediated by ZEB1, which supports H9M-independent survival. MiR-204 negatively regulates ZEB1 and can be pharmacologically reactivated with hypomethylating agents, thereby restoring sensitivity to MENIN inhibition and providing a mechanistic rationale for combination therapy'. https://library.ehaweb.org/eha/2026/eha-2026/4206672/liam.macphee.zeb1.defines.a.targetable.menin-inhibitor.escape.program.in.kmt2a.html
0 · Reply
dgbio
dgbio May. 12 at 8:55 PM
$SNDX Kura reports only 6m revenue for Komzifti vs estimated 15m revenue for Revuforj in NPM1.
0 · Reply
Burning_Cash
Burning_Cash May. 12 at 8:22 PM
$SNDX At least KURA didn’t hit it out of the park. Maybe we’ll recover somewhat tomorrow. Don’t see anything to suggest the option guy(s) will be making bank, though.
1 · Reply
Night_Owl_Biotech
Night_Owl_Biotech May. 12 at 6:16 PM
$SNDX investors should go to the KURA page here on StockTwits. A user named Massimo or the like published an excerpt from a KURA presentation to be made in 1 month. Ziftomenib's CRc rates are north of 90%. At a minimum, that's going to get some attention. @outlawinvestor1 also posted a good comparison of the 2 drugs 1 day does not make a trend but shame on SNDX for not selling to Incyte when they could have.
8 · Reply
Burning_Cash
Burning_Cash May. 12 at 6:03 PM
$SNDX Or maybe not… 😅
0 · Reply
Night_Owl_Biotech
Night_Owl_Biotech May. 12 at 5:43 PM
This is not investment advice but just for entertainment purposes remember someone, or at most 4 investors, collectively invested over $400,000 the last 2 trading days to purchase 4,500 $SNDX $22 calls expiring this Friday (450,000 shares). Whoever he/she/they may be, SNDX needs to hit roughly $22.70 by Friday for these investments to simply break even (of course the bid right now is $0.50 per Fidelity). The attachment (left side) reposts our post from last Friday summarizing the day & the detail trading in these calls over the last 5 days. We see minor additional purchases but no meaningful sales. Good luck to whoever you are. We're rooting for you.
1 · Reply
chole1
chole1 May. 12 at 5:42 PM
$SNDX todays down move is probably due to Kura's PR regarding their 1st line data for their menin inh plus 7+3, lets see what Kura's Q1 revenue will look like today post market to see how competitive their launch is against SNDX SNDX biggie for me is the IPF P2 data in H2
0 · Reply
FetchDog
FetchDog May. 12 at 5:42 PM
$SNDX Eat my words. Data from $KURA today is looking just too good. Sold my SNDX today, bought a starter position in KURA
1 · Reply
Jarvis7424
Jarvis7424 May. 12 at 5:32 PM
$SNDX just waiting for that buyout
0 · Reply
AdiDasRom
AdiDasRom May. 12 at 5:20 PM
$SNDX Bullish. Don't believe in this decline.
0 · Reply
rabbitsoup
rabbitsoup May. 12 at 2:40 AM
$SNDX Good news -short is interest down another bit over 1mm shares from 4/15/26 to 4/30/26 now @ 19,911,327- Lowest in a long time..... I'm really hoping and optimistic $SNDX will do a great job at ASCO. This is currently my #1 conviction for organic upside or a buyout, and I own plenty of stock much cheaper and not selling.
0 · Reply
traystocks
traystocks May. 11 at 6:28 PM
$SNDX Who wants to bet that @Fairvalue10 is in this?
0 · Reply