Market Cap 3.20B
Revenue (ttm) 0.00
Net Income (ttm) -512.54M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 3,892,100
Avg Vol 1,667,792
Day's Range N/A - N/A
Shares Out 158.59M
Stochastic %K 43%
Beta 1.02
Analysts Strong Sell
Price Target $32.93

Company Profile

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement thera...

Industry: Biotechnology
Sector: Healthcare
Phone: 650 866 8547
Address:
161 Oyster Point Boulevard, South San Francisco, United States
PatienceisGrace
PatienceisGrace Mar. 20 at 12:47 PM
$DNLI $RCKT responding to this comment: Key Recent Single-Arm Study Approvals Waskyra (December 2025): Approved to treat Wiskott-Aldrich Syndrome based on two open-label, single-arm studies and an expanded access program. Sevabertinib (Hyrnuo) (November 2025): Granted accelerated approval for patients with HER2-mutated locally advanced or metastatic non-squamous NSCLC, supported by single-arm data. Papzimeos (September 2025): Approved for recurrent respiratory papillomatosis (RRP), based on a single-arm, open-label Phase 1/2 study that prioritized the percentage of patients needing no surgeries post-treatment. ANKTIVA (August 2024): Approved for BCG-unresponsive non-muscle-invasive bladder cancer (NMIBC) based on a single-arm study of 88 patients. JenaValve Trilogy (March 2026): Received approval for high-risk aortic regurgitation based on the single-arm Align-AR study.
2 · Reply
Smellmahass
Smellmahass Mar. 20 at 7:47 AM
$DNLI This and $RCKT. They only use single arm so why would fda approve them? Fda declined rgnx and atra based on being single arm right?
2 · Reply
BullDonald
BullDonald Mar. 19 at 4:00 PM
$DNLI Yesterday was a sell everything market. Everything is going to shit. am done for the Year almost. Lets go already. give me a boost. This War may hurt every ticker soon.
0 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS Mar. 19 at 3:14 PM
$BIIB $CELC $DNLI $TVTX —->pdufa tomorrow RYTM!
0 · Reply
DoctrBenway
DoctrBenway Mar. 19 at 2:13 PM
$DNLI For want of more capital a prime adding opportunity is missed. 🥲
0 · Reply
onlyGreenPlz
onlyGreenPlz Mar. 19 at 4:34 AM
$DNLI Bullish pennant forming. Breakout?
0 · Reply
BullDonald
BullDonald Mar. 17 at 6:28 PM
$DNLI Call summary (Inference) > discussion on Tivi - enthusiasm in the voice. > Good engagement with the FDA. confidence on the DATA. > Mis calculation issues solved, no Data issue. > Value proposition is huge. > label prediction : not yet fully prepared. NO clear answer > No finalized pricing Yet. > Pompeii, 2 Alzheimer - 3 pipelines will be added this year. > Bla bla bla on different diseases > preparation for the Launch ( Positive about the Approval ) I am loaded to the tits. LFG🚀
0 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS Mar. 16 at 8:24 PM
$TVTX $BIIB $CELC $DNLI ALL WINNERS. GET IN WHILE YOU CAN FOLKS
0 · Reply
BullDonald
BullDonald Mar. 16 at 4:40 PM
$DNLI Ladies and Gentlemen Hop IN we are going to the MOON 🚀
0 · Reply
BullDonald
BullDonald Mar. 12 at 4:51 PM
$DNLI Cant have enough. Added another 2K around 20. LFG 🚀
0 · Reply
Latest News on DNLI
Denali Therapeutics Inc. (DNLI) Analyst/Investor Day Transcript

Dec 5, 2025, 2:58 AM EST - 3 months ago

Denali Therapeutics Inc. (DNLI) Analyst/Investor Day Transcript


Denali: Regulatory Delay Is A Strategic Opportunity

Dec 2, 2025, 8:09 AM EST - 3 months ago

Denali: Regulatory Delay Is A Strategic Opportunity


The Best Small-Cap Stocks to Buy Now

Aug 12, 2025, 9:47 AM EDT - 7 months ago

The Best Small-Cap Stocks to Buy Now

KYMR WAY


Denali Therapeutics: Vast Pipeline, First Approval Up Ahead

Mar 20, 2025, 2:16 PM EDT - 1 year ago

Denali Therapeutics: Vast Pipeline, First Approval Up Ahead


Why Is Denali Therapeutics Stock Trading Higher On Wednesday?

Jan 15, 2025, 2:26 PM EST - 1 year ago

Why Is Denali Therapeutics Stock Trading Higher On Wednesday?


Denali Therapeutics ALS drug fails in mid-stage trial

Jan 6, 2025, 4:43 PM EST - 1 year ago

Denali Therapeutics ALS drug fails in mid-stage trial


Denali Has A Neurodegenerative Edge Despite Market Skepticism

Nov 16, 2024, 8:56 AM EST - 1 year ago

Denali Has A Neurodegenerative Edge Despite Market Skepticism


PatienceisGrace
PatienceisGrace Mar. 20 at 12:47 PM
$DNLI $RCKT responding to this comment: Key Recent Single-Arm Study Approvals Waskyra (December 2025): Approved to treat Wiskott-Aldrich Syndrome based on two open-label, single-arm studies and an expanded access program. Sevabertinib (Hyrnuo) (November 2025): Granted accelerated approval for patients with HER2-mutated locally advanced or metastatic non-squamous NSCLC, supported by single-arm data. Papzimeos (September 2025): Approved for recurrent respiratory papillomatosis (RRP), based on a single-arm, open-label Phase 1/2 study that prioritized the percentage of patients needing no surgeries post-treatment. ANKTIVA (August 2024): Approved for BCG-unresponsive non-muscle-invasive bladder cancer (NMIBC) based on a single-arm study of 88 patients. JenaValve Trilogy (March 2026): Received approval for high-risk aortic regurgitation based on the single-arm Align-AR study.
2 · Reply
Smellmahass
Smellmahass Mar. 20 at 7:47 AM
$DNLI This and $RCKT. They only use single arm so why would fda approve them? Fda declined rgnx and atra based on being single arm right?
2 · Reply
BullDonald
BullDonald Mar. 19 at 4:00 PM
$DNLI Yesterday was a sell everything market. Everything is going to shit. am done for the Year almost. Lets go already. give me a boost. This War may hurt every ticker soon.
0 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS Mar. 19 at 3:14 PM
$BIIB $CELC $DNLI $TVTX —->pdufa tomorrow RYTM!
0 · Reply
DoctrBenway
DoctrBenway Mar. 19 at 2:13 PM
$DNLI For want of more capital a prime adding opportunity is missed. 🥲
0 · Reply
onlyGreenPlz
onlyGreenPlz Mar. 19 at 4:34 AM
$DNLI Bullish pennant forming. Breakout?
0 · Reply
BullDonald
BullDonald Mar. 17 at 6:28 PM
$DNLI Call summary (Inference) > discussion on Tivi - enthusiasm in the voice. > Good engagement with the FDA. confidence on the DATA. > Mis calculation issues solved, no Data issue. > Value proposition is huge. > label prediction : not yet fully prepared. NO clear answer > No finalized pricing Yet. > Pompeii, 2 Alzheimer - 3 pipelines will be added this year. > Bla bla bla on different diseases > preparation for the Launch ( Positive about the Approval ) I am loaded to the tits. LFG🚀
0 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS Mar. 16 at 8:24 PM
$TVTX $BIIB $CELC $DNLI ALL WINNERS. GET IN WHILE YOU CAN FOLKS
0 · Reply
BullDonald
BullDonald Mar. 16 at 4:40 PM
$DNLI Ladies and Gentlemen Hop IN we are going to the MOON 🚀
0 · Reply
BullDonald
BullDonald Mar. 12 at 4:51 PM
$DNLI Cant have enough. Added another 2K around 20. LFG 🚀
0 · Reply
Drumpito
Drumpito Mar. 12 at 3:01 PM
$DNLI This will be Huuuuuuuge !! I am In at 20.
0 · Reply
BullDonald
BullDonald Mar. 12 at 1:56 PM
$DNLI Added 5K more shares. Averaged up. Loaded to the tits. LFG 🚀
0 · Reply
ZacksResearch
ZacksResearch Mar. 11 at 4:23 PM
$DNLI just ripped 11.8% in a month — but the real catalyst is still ahead. Investors are watching an April 5, 2026 FDA decision on tividenofusp alfa for Hunter syndrome, which could be a major growth driver and is clearly fueling the recent momentum. 👀 Big biotech catalysts can move fast — see the full setup before the decision 👉 https://www.zacks.com/stock/news/2882427/denali-gains-118-in-a-month-buy-sell-or-hold-the-stock?cid=sm-stocktwits-2-2882427-teaser-36991&ADID=SYND_STOCKTWITS_TWEET_2_2882427_TEASER_36991
0 · Reply
ZacksResearch
ZacksResearch Mar. 11 at 3:23 PM
$DNLI surges 11.8% in a month — what’s fueling the rally? 🚀 Investor optimism is high for the potential approval of tividenofusp alfa for Hunter syndrome, with a key FDA decision expected on April 5, 2026. Positive Breakthrough Therapy, Fast Track, Orphan Drug, and Rare Pediatric Disease designations underscore the drug's potential. 📈 See what makes the investment case strong for DNLI 👉 https://www.zacks.com/stock/news/2882427/denali-gains-118-in-a-month-buy-sell-or-hold-the-stock?cid=sm-stocktwits-2-2882427-body-36992&ADID=SYND_STOCKTWITS_TWEET_2_2882427_BODY_36992
0 · Reply
BullDonald
BullDonald Mar. 11 at 2:20 PM
$DNLI Order Placed ! Fill it . I need more.
0 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS Mar. 10 at 6:08 PM
$DNLI LETS GO
1 · Reply
CharlieeMungerTWITS
CharlieeMungerTWITS Mar. 10 at 5:09 PM
$DNLI $30 stock if fda approves Hunter syndrome indication
0 · Reply
NorthStarStats
NorthStarStats Mar. 10 at 2:30 AM
Output from a custom NorthStarStats momentum scanner highlighting stocks with strengthening price structure and momentum. Setups to watch and study — not trade recommendations. $PYXS Score: 95.00 | >350% implied upside|Earnings, $AVGO Score 95.00 |100B+ in AI chip revenue expected, $GHRS Score: 95.00 |Solid Cash Runway| $42 upgrade, $DNLI Score: 95.00 |PDUFA tividenofusp alfa April 5, $LYV Score 73.00 |DOJ Setlmnt|Venue Nation Expansion
0 · Reply
BullDonald
BullDonald Mar. 9 at 7:41 PM
$DNLI Call started !
0 · Reply
Doozio
Doozio Mar. 9 at 3:34 PM
chop chop huckleberries wen the DAWN of a 🧠👀 became $DNLI of da 🐑 during 🐒🍌🧠⏰♾️
0 · Reply
BullDonald
BullDonald Mar. 7 at 1:51 PM
$DNLI - 80%+ institution ownership, - Big Pharma backing the pipelines, - The sentiment it Optimistic for the approval. - Low volume fluctuation caused by the Retail swinging it for a dollar or two. - Strong support level is 18. Should Bounce hard after shaking the paper hands. If it tests 18, I may add some to my position.🚀
0 · Reply
dgbio
dgbio Mar. 7 at 2:02 AM
$DNLI Prasad is fired again
0 · Reply