Market Cap 3.19B
Revenue (ttm) 0.00
Net Income (ttm) -422.77M
EPS (ttm) N/A
PE Ratio 0.00
Forward PE N/A
Profit Margin 0.00%
Debt to Equity Ratio 0.00
Volume 1,727,500
Avg Vol 1,672,384
Day's Range N/A - N/A
Shares Out 146.66M
Stochastic %K 61%
Beta 1.05
Analysts Strong Sell
Price Target $32.86

Company Profile

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; DNL343 eIF2B activator program for amyotrophic lateral sclerosis; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Synd...

Industry: Biotechnology
Sector: Healthcare
Phone: 650 866 8547
Address:
161 Oyster Point Boulevard, South San Francisco, United States
ZacksResearch
ZacksResearch Feb. 3 at 2:03 PM
Q4 earnings season — these 5 drug & biotech names could surprise to the upside $ZTS, $PCRX, $APLS, $ACAD, and $DNLI are highlighted as poised to beat on fourth-quarter 2025 earnings, setting up a potential outperformance theme investors should have on their radar. See which drug & biotech stocks could deliver earnings upside 👉 https://www.zacks.com/stock/news/2827958/5-drugbiotech-stocks-likely-to-outperform-q4-earnings-estimates?cid=sm-stocktwits-2-2827958-teaser-31624&ADID=SYND_STOCKTWITS_TWEET_2_2827958_TEASER_31624
0 · Reply
BullDonald
BullDonald Feb. 3 at 12:01 AM
$DNLI the PT is changing fast for good. Once it stabilizes above 23 the move to wards 30 is certain. M ready to add more.
0 · Reply
BullDonald
BullDonald Feb. 2 at 3:08 PM
$DNLI and $ETON in both my base price is the same. DNLI is already at MOON where are ETON kinda eating DUST, Zero movement and volume. seems we need to send some one to knock the door and ask any one is here to ETON Doors.
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BullDonald
BullDonald Jan. 30 at 5:19 PM
$DNLI Looking Great !
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PinTheInvestor
PinTheInvestor Jan. 30 at 2:04 PM
Hunter Syndrome is lining up nicely for $DNLI , particularly after $RGNX's AAV issues. The "continued DNL310 follow-up" presentation for on Thursday is icing. I am actually more interested in the Sanfilippo presentation. In these preliminary ph1/2 results we want to see safety (almost a given) and efficacy at the biomarker level (also very likely - qualitatively reported in Nov 2024). If they say *anything* about preserving development in the <28 mo cohort, that's a HUGE win. Fingers crossed for the stock and for the patient community.
0 · Reply
BullDonald
BullDonald Jan. 30 at 12:45 AM
$DNLI PRESSURE COOKER at this point.
0 · Reply
Eagley3k
Eagley3k Jan. 29 at 7:35 PM
$DNLI "Denali will present initial clinical data from the fully enrolled, ongoing Phase 1/2 study of DNL126 at the 2026 WORLDSymposiumTM (February 3-6, 2026). The Phase 1/2 study is designed to support an accelerated approval path in Sanfilippo syndrome Type A. Planning for a global Phase 3 confirmatory study is ongoing." Moving in anticipation of data readout next week. I see new highs on positive readout.
0 · Reply
BullDonald
BullDonald Jan. 29 at 6:11 PM
$DNLI This thing is a Blast.đź’Ą once crosses 23, Move towards 30 will start. Load the Boat.
0 · Reply
Daddy044
Daddy044 Jan. 29 at 12:32 PM
$IMMX A friend just told me about a Jeffries report that claimed approximately 72% of drugs with Breakthrough. The remaining roughly 43% fail because of missed primary endpoints not regulatory rejection. Names to watch include $IMMX, $BIIB, $BBIO, $DNLI, $AKRO (sold), $DYN$STOK$PRAX is a precision neuro trio.
1 · Reply
BullDonald
BullDonald Jan. 29 at 12:53 AM
$DNLI $30 is brewing ! here.
0 · Reply
Latest News on DNLI
Denali Therapeutics Inc. (DNLI) Analyst/Investor Day Transcript

Dec 5, 2025, 2:58 AM EST - 2 months ago

Denali Therapeutics Inc. (DNLI) Analyst/Investor Day Transcript


Denali: Regulatory Delay Is A Strategic Opportunity

Dec 2, 2025, 8:09 AM EST - 2 months ago

Denali: Regulatory Delay Is A Strategic Opportunity


The Best Small-Cap Stocks to Buy Now

Aug 12, 2025, 9:47 AM EDT - 6 months ago

The Best Small-Cap Stocks to Buy Now

KYMR WAY


Denali Therapeutics: Vast Pipeline, First Approval Up Ahead

Mar 20, 2025, 2:16 PM EDT - 11 months ago

Denali Therapeutics: Vast Pipeline, First Approval Up Ahead


Why Is Denali Therapeutics Stock Trading Higher On Wednesday?

Jan 15, 2025, 2:26 PM EST - 1 year ago

Why Is Denali Therapeutics Stock Trading Higher On Wednesday?


Denali Therapeutics ALS drug fails in mid-stage trial

Jan 6, 2025, 4:43 PM EST - 1 year ago

Denali Therapeutics ALS drug fails in mid-stage trial


Denali Has A Neurodegenerative Edge Despite Market Skepticism

Nov 16, 2024, 8:56 AM EST - 1 year ago

Denali Has A Neurodegenerative Edge Despite Market Skepticism


Denali's New Summit: Changing Hunter Syndrome Landscape

Oct 2, 2023, 5:26 AM EDT - 2 years ago

Denali's New Summit: Changing Hunter Syndrome Landscape


ZacksResearch
ZacksResearch Feb. 3 at 2:03 PM
Q4 earnings season — these 5 drug & biotech names could surprise to the upside $ZTS, $PCRX, $APLS, $ACAD, and $DNLI are highlighted as poised to beat on fourth-quarter 2025 earnings, setting up a potential outperformance theme investors should have on their radar. See which drug & biotech stocks could deliver earnings upside 👉 https://www.zacks.com/stock/news/2827958/5-drugbiotech-stocks-likely-to-outperform-q4-earnings-estimates?cid=sm-stocktwits-2-2827958-teaser-31624&ADID=SYND_STOCKTWITS_TWEET_2_2827958_TEASER_31624
0 · Reply
BullDonald
BullDonald Feb. 3 at 12:01 AM
$DNLI the PT is changing fast for good. Once it stabilizes above 23 the move to wards 30 is certain. M ready to add more.
0 · Reply
BullDonald
BullDonald Feb. 2 at 3:08 PM
$DNLI and $ETON in both my base price is the same. DNLI is already at MOON where are ETON kinda eating DUST, Zero movement and volume. seems we need to send some one to knock the door and ask any one is here to ETON Doors.
0 · Reply
BullDonald
BullDonald Jan. 30 at 5:19 PM
$DNLI Looking Great !
0 · Reply
PinTheInvestor
PinTheInvestor Jan. 30 at 2:04 PM
Hunter Syndrome is lining up nicely for $DNLI , particularly after $RGNX's AAV issues. The "continued DNL310 follow-up" presentation for on Thursday is icing. I am actually more interested in the Sanfilippo presentation. In these preliminary ph1/2 results we want to see safety (almost a given) and efficacy at the biomarker level (also very likely - qualitatively reported in Nov 2024). If they say *anything* about preserving development in the <28 mo cohort, that's a HUGE win. Fingers crossed for the stock and for the patient community.
0 · Reply
BullDonald
BullDonald Jan. 30 at 12:45 AM
$DNLI PRESSURE COOKER at this point.
0 · Reply
Eagley3k
Eagley3k Jan. 29 at 7:35 PM
$DNLI "Denali will present initial clinical data from the fully enrolled, ongoing Phase 1/2 study of DNL126 at the 2026 WORLDSymposiumTM (February 3-6, 2026). The Phase 1/2 study is designed to support an accelerated approval path in Sanfilippo syndrome Type A. Planning for a global Phase 3 confirmatory study is ongoing." Moving in anticipation of data readout next week. I see new highs on positive readout.
0 · Reply
BullDonald
BullDonald Jan. 29 at 6:11 PM
$DNLI This thing is a Blast.đź’Ą once crosses 23, Move towards 30 will start. Load the Boat.
0 · Reply
Daddy044
Daddy044 Jan. 29 at 12:32 PM
$IMMX A friend just told me about a Jeffries report that claimed approximately 72% of drugs with Breakthrough. The remaining roughly 43% fail because of missed primary endpoints not regulatory rejection. Names to watch include $IMMX, $BIIB, $BBIO, $DNLI, $AKRO (sold), $DYN$STOK$PRAX is a precision neuro trio.
1 · Reply
BullDonald
BullDonald Jan. 29 at 12:53 AM
$DNLI $30 is brewing ! here.
0 · Reply
BullDonald
BullDonald Jan. 28 at 9:56 PM
$DNLI Planning on Averaging UP again $VNDA Planning on Averaging UP again $ETON Hold $NRXP Watching
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Longbuy1
Longbuy1 Jan. 28 at 6:29 PM
$DNLI $RGNX it's saying that retail is stupid and sell your shares cheap,.
0 · Reply
Longbuy1
Longbuy1 Jan. 28 at 6:04 PM
$DNLI $RGNX DNL310 is in phase 2\3, screw your paid written article.
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prismmarketview
prismmarketview Jan. 28 at 5:54 PM
An FDA review delay and new safety overhang for Regenxbio’s (NASDAQ: $RGNX) RGX‑121 in Hunter syndrome are giving Denali’s Denali Therapeutics (NASDAQ: $DNLI) tividenofusp alfa a clearer shot at first‑to‑market status in this rare‑disease race. https://prismmarketview.com/fda-delay-for-regenxbio-may-open-the-door-for-denali-in-hunter-syndrome-race/
1 · Reply
dgbio
dgbio Jan. 28 at 5:41 PM
$DNLI Clinical hold on a somewhat competing product from Regenxbio should be seen as a somewhat positive for Denali. The difference in delivery mechanisms, AAV vector vs ERT, means no spillover impact on Denali's product.
0 · Reply
S_Franconi
S_Franconi Jan. 28 at 3:26 PM
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lebranjames
lebranjames Jan. 28 at 12:41 PM
$DNLI take notes 📝 can’t afford a CRL like $RGNX
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BullDonald
BullDonald Jan. 26 at 1:39 PM
$DNLI we will see a move towards $30 here.
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onlyGreenPlz
onlyGreenPlz Jan. 25 at 8:09 AM
$DNLI Awaiting DNL310 PDUFA. Likely already priced in but looking for $30-35 range. Above that would be cherry on top.
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BullDonald
BullDonald Jan. 23 at 1:00 PM
$DNLI Did not expect it to move at this rate ... PT 30 is insight at this point.
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BullDonald
BullDonald Jan. 22 at 6:11 PM
$DNLI AVERAGED UP for the SECOND time Baby $ETON I need more of it. $VNDA I Love you too, AVERAGED UP Today $ESPR LOCO fiancials, No Touchy Touchy
0 · Reply
BullDonald
BullDonald Jan. 22 at 3:29 PM
$DNLI Just like that we are at $ 20 we will see $ 25 in weeks . Load the F up.
0 · Reply